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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q21
Chromosome location (bp)
95165513 - 95232541
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway 1. May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0016239[positive regulation of macroautophagy] GO:0016491[oxidoreductase activity] GO:0016684[oxidoreductase activity, acting on peroxide as acceptor] GO:0034198[cellular response to amino acid starvation] GO:0042149[cellular response to glucose starvation] GO:0051716[cellular response to stimulus] GO:0061700[GATOR2 complex] GO:0070728[leucine binding] GO:0071233[cellular response to leucine] GO:1901031[regulation of response to reactive oxygen species] GO:1904262[negative regulation of TORC1 signaling] GO:1990253[cellular response to leucine starvation]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0016239[positive regulation of macroautophagy] GO:0016491[oxidoreductase activity] GO:0016684[oxidoreductase activity, acting on peroxide as acceptor] GO:0034198[cellular response to amino acid starvation] GO:0042149[cellular response to glucose starvation] GO:0051716[cellular response to stimulus] GO:0061700[GATOR2 complex] GO:0070728[leucine binding] GO:0071233[cellular response to leucine] GO:1901031[regulation of response to reactive oxygen species] GO:1904262[negative regulation of TORC1 signaling] GO:1990253[cellular response to leucine starvation]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0016239[positive regulation of macroautophagy] GO:0016491[oxidoreductase activity] GO:0016684[oxidoreductase activity, acting on peroxide as acceptor] GO:0031932[TORC2 complex] GO:0032868[response to insulin] GO:0034198[cellular response to amino acid starvation] GO:0038203[TORC2 signaling] GO:0042149[cellular response to glucose starvation] GO:0042593[glucose homeostasis] GO:0046626[regulation of insulin receptor signaling pathway] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0061700[GATOR2 complex] GO:0070728[leucine binding] GO:0071230[cellular response to amino acid stimulus] GO:0071233[cellular response to leucine] GO:1901031[regulation of response to reactive oxygen species] GO:1904262[negative regulation of TORC1 signaling] GO:1990253[cellular response to leucine starvation]
The Human Protein Atlas project is funded
