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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q24.2
Chromosome location (bp)
126282497 - 126298845
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P58753 [Direct mapping] Toll/interleukin-1 receptor domain-containing adapter protein
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002376[immune system process] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007250[activation of NF-kappaB-inducing kinase activity] GO:0016020[membrane] GO:0030099[myeloid cell differentiation] GO:0030139[endocytic vesicle] GO:0030674[protein-macromolecule adaptor activity] GO:0030890[positive regulation of B cell proliferation] GO:0031334[positive regulation of protein-containing complex assembly] GO:0032496[response to lipopolysaccharide] GO:0032587[ruffle membrane] GO:0032648[regulation of interferon-beta production] GO:0032735[positive regulation of interleukin-12 production] GO:0032738[positive regulation of interleukin-15 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032872[regulation of stress-activated MAPK cascade] GO:0034137[positive regulation of toll-like receptor 2 signaling pathway] GO:0034141[positive regulation of toll-like receptor 3 signaling pathway] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0035662[Toll-like receptor 4 binding] GO:0035663[Toll-like receptor 2 binding] GO:0035665[TIRAP-dependent toll-like receptor 4 signaling pathway] GO:0042802[identical protein binding] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0045088[regulation of innate immune response] GO:0045089[positive regulation of innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0050830[defense response to Gram-positive bacterium] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070935[3'-UTR-mediated mRNA stabilization] GO:0071221[cellular response to bacterial lipopeptide] GO:0071223[cellular response to lipoteichoic acid] GO:0090023[positive regulation of neutrophil chemotaxis] GO:2000340[positive regulation of chemokine (C-X-C motif) ligand 1 production] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production]
P58753 [Direct mapping] Toll/interleukin-1 receptor domain-containing adapter protein
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A0A024R3M4 [Target identity:100%; Query identity:100%] Toll/interleukin-1 receptor domain-containing adapter protein
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0002376[immune system process] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007250[activation of NF-kappaB-inducing kinase activity] GO:0016020[membrane] GO:0030099[myeloid cell differentiation] GO:0030139[endocytic vesicle] GO:0030674[protein-macromolecule adaptor activity] GO:0030890[positive regulation of B cell proliferation] GO:0031334[positive regulation of protein-containing complex assembly] GO:0032496[response to lipopolysaccharide] GO:0032587[ruffle membrane] GO:0032648[regulation of interferon-beta production] GO:0032735[positive regulation of interleukin-12 production] GO:0032738[positive regulation of interleukin-15 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032872[regulation of stress-activated MAPK cascade] GO:0034137[positive regulation of toll-like receptor 2 signaling pathway] GO:0034141[positive regulation of toll-like receptor 3 signaling pathway] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0035662[Toll-like receptor 4 binding] GO:0035663[Toll-like receptor 2 binding] GO:0035665[TIRAP-dependent toll-like receptor 4 signaling pathway] GO:0042802[identical protein binding] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0045088[regulation of innate immune response] GO:0045089[positive regulation of innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0050830[defense response to Gram-positive bacterium] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070935[3'-UTR-mediated mRNA stabilization] GO:0071221[cellular response to bacterial lipopeptide] GO:0071223[cellular response to lipoteichoic acid] GO:0090023[positive regulation of neutrophil chemotaxis] GO:2000340[positive regulation of chemokine (C-X-C motif) ligand 1 production] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production]
P58753 [Direct mapping] Toll/interleukin-1 receptor domain-containing adapter protein
Show all
A0A024R3M4 [Target identity:100%; Query identity:100%] Toll/interleukin-1 receptor domain-containing adapter protein
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0002376[immune system process] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007250[activation of NF-kappaB-inducing kinase activity] GO:0016020[membrane] GO:0030099[myeloid cell differentiation] GO:0030139[endocytic vesicle] GO:0030674[protein-macromolecule adaptor activity] GO:0030890[positive regulation of B cell proliferation] GO:0031334[positive regulation of protein-containing complex assembly] GO:0032496[response to lipopolysaccharide] GO:0032587[ruffle membrane] GO:0032648[regulation of interferon-beta production] GO:0032735[positive regulation of interleukin-12 production] GO:0032738[positive regulation of interleukin-15 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032872[regulation of stress-activated MAPK cascade] GO:0034137[positive regulation of toll-like receptor 2 signaling pathway] GO:0034141[positive regulation of toll-like receptor 3 signaling pathway] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0035662[Toll-like receptor 4 binding] GO:0035663[Toll-like receptor 2 binding] GO:0035665[TIRAP-dependent toll-like receptor 4 signaling pathway] GO:0042802[identical protein binding] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0045088[regulation of innate immune response] GO:0045089[positive regulation of innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0050830[defense response to Gram-positive bacterium] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070935[3'-UTR-mediated mRNA stabilization] GO:0071221[cellular response to bacterial lipopeptide] GO:0071223[cellular response to lipoteichoic acid] GO:0090023[positive regulation of neutrophil chemotaxis] GO:2000340[positive regulation of chemokine (C-X-C motif) ligand 1 production] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production]
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