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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q25.2
Chromosome location (bp)
110871795 - 110900006
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q53EL6 [Direct mapping] Programmed cell death protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0030509[BMP signaling pathway] GO:0034393[positive regulation of smooth muscle cell apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043508[negative regulation of JUN kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0050729[positive regulation of inflammatory response] GO:0051246[regulation of protein metabolic process] GO:0060940[epithelial to mesenchymal transition involved in cardiac fibroblast development] GO:0071222[cellular response to lipopolysaccharide] GO:1900016[negative regulation of cytokine production involved in inflammatory response] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904761[negative regulation of myofibroblast differentiation] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1905461[positive regulation of vascular associated smooth muscle cell apoptotic process] GO:2000353[positive regulation of endothelial cell apoptotic process]
Q53EL6 [Direct mapping] Programmed cell death protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0030509[BMP signaling pathway] GO:0043508[negative regulation of JUN kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0050729[positive regulation of inflammatory response] GO:0060940[epithelial to mesenchymal transition involved in cardiac fibroblast development] GO:0071222[cellular response to lipopolysaccharide] GO:1900016[negative regulation of cytokine production involved in inflammatory response] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904761[negative regulation of myofibroblast differentiation] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1905461[positive regulation of vascular associated smooth muscle cell apoptotic process] GO:2000353[positive regulation of endothelial cell apoptotic process]
The Human Protein Atlas project is funded
