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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Potential drug targets RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q34.3
Chromosome location (bp)
176683538 - 176792922
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Growth factor, Mitogen
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis, Differentiation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P49767 [Direct mapping] Vascular endothelial growth factor C
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Transporters Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of skin Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001666[response to hypoxia] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002040[sprouting angiogenesis] GO:0002052[positive regulation of neuroblast proliferation] GO:0005172[vascular endothelial growth factor receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006929[substrate-dependent cell migration] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0009887[animal organ morphogenesis] GO:0014009[glial cell proliferation] GO:0016020[membrane] GO:0016331[morphogenesis of embryonic epithelium] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030947[regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031093[platelet alpha granule lumen] GO:0031954[positive regulation of protein autophosphorylation] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0042056[chemoattractant activity] GO:0043185[vascular endothelial growth factor receptor 3 binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045668[negative regulation of osteoblast differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045776[negative regulation of blood pressure] GO:0045860[positive regulation of protein kinase activity] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048018[receptor ligand activity] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050714[positive regulation of protein secretion] GO:0050918[positive chemotaxis] GO:0050930[induction of positive chemotaxis] GO:0051781[positive regulation of cell division] GO:0060252[positive regulation of glial cell proliferation] GO:0060754[positive regulation of mast cell chemotaxis] GO:1901492[positive regulation of lymphangiogenesis] GO:1902462[positive regulation of mesenchymal stem cell proliferation] GO:1990830[cellular response to leukemia inhibitory factor]
The Human Protein Atlas project is funded
