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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p24.2
Chromosome location (bp)
24117153 - 24495756
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007605[sensory perception of sound] GO:0007621[negative regulation of female receptivity] GO:0008016[regulation of heart contraction] GO:0008050[female courtship behavior] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0009887[animal organ morphogenesis] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046549[retinal cone cell development] GO:0046872[metal ion binding] GO:0060509[type I pneumocyte differentiation] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:0097474[retinal cone cell apoptotic process] GO:1990837[sequence-specific double-stranded DNA binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001223[transcription coactivator binding] GO:0002154[thyroid hormone mediated signaling pathway] GO:0002157[positive regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0016604[nuclear body] GO:0019899[enzyme binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0070324[thyroid hormone binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097067[cellular response to thyroid hormone stimulus] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
