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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q12
Chromosome location (bp)
32329298 - 32837684
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0001508[action potential] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005635[nuclear envelope] GO:0005737[cytoplasm] GO:0005901[caveola] GO:0006605[protein targeting] GO:0008179[adenylate cyclase binding] GO:0010738[regulation of protein kinase A signaling] GO:0010880[regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0014701[junctional sarcoplasmic reticulum membrane] GO:0014704[intercalated disc] GO:0016020[membrane] GO:0016529[sarcoplasmic reticulum] GO:0019933[cAMP-mediated signaling] GO:0030307[positive regulation of cell growth] GO:0030315[T-tubule] GO:0031965[nuclear membrane] GO:0034237[protein kinase A regulatory subunit binding] GO:0034704[calcium channel complex] GO:0043495[protein-membrane adaptor activity] GO:0044325[transmembrane transporter binding] GO:0048471[perinuclear region of cytoplasm] GO:0051018[protein kinase A binding] GO:0051281[positive regulation of release of sequestered calcium ion into cytosol] GO:0060090[molecular adaptor activity] GO:0060306[regulation of membrane repolarization] GO:0060316[positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0061051[positive regulation of cell growth involved in cardiac muscle cell development] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0071320[cellular response to cAMP] GO:0071345[cellular response to cytokine stimulus] GO:1901381[positive regulation of potassium ion transmembrane transport] GO:1902261[positive regulation of delayed rectifier potassium channel activity]
The Human Protein Atlas project is funded
