GENERAL INFORMATIONi
Gene namei FER
Synonyms PPP1R74, TYK3
Gene descriptioni FER tyrosine kinase
Protein classi Enzymes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 5
Cytoband q21.3
Chromosome location (bp) 108747841 - 109196841
Number of transcriptsi 3
Ensembl ENSG00000151422 (version 109)
Entrez gene 2241
HGNC HGNC:3655
UniProt P16591 (UniProt - Evidence at protein level)
neXtProt NX_P16591
GeneCards FER
Antibodypedia FER antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. show less
Molecular function (UniProt)i Kinase, Transferase, Tyrosine-protein kinase
Ligand (UniProt)i ATP-binding, Lipid-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
FER-201
ENSP00000281092
ENST00000281092
P16591
[Direct mapping] Tyrosine-protein kinase Fer
Show all
W0S0X4
[Target identity:100%; Query identity:100%] Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000785 [chromatin]
GO:0001932 [regulation of protein phosphorylation]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0007281 [germ cell development]
GO:0008092 [cytoskeletal protein binding]
GO:0008157 [protein phosphatase 1 binding]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008584 [male gonad development]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010762 [regulation of fibroblast migration]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031267 [small GTPase binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032496 [response to lipopolysaccharide]
GO:0032869 [cellular response to insulin stimulus]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0034333 [adherens junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035426 [extracellular matrix-cell signaling]
GO:0035556 [intracellular signal transduction]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0036119 [response to platelet-derived growth factor]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038109 [Kit signaling pathway]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0042995 [cell projection]
GO:0043304 [regulation of mast cell degranulation]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0045087 [innate immune response]
GO:0045098 [type III intermediate filament]
GO:0045295 [gamma-catenin binding]
GO:0045296 [cadherin binding]
GO:0046777 [protein autophosphorylation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0050904 [diapedesis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060009 [Sertoli cell development]
GO:0070097 [delta-catenin binding]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0120179 [adherens junction disassembly]
GO:1990782 [protein tyrosine kinase binding]
Show all
 822 aa
94.6 kDa 		No 0
FER-202
ENSP00000394297
ENST00000438717
W0S4B9
[Direct mapping] Tyrosine-protein kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008283 [cell population proliferation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030335 [positive regulation of cell migration]
GO:0031532 [actin cytoskeleton reorganization]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 411 aa
47 kDa 		No 0
FER-209
ENSP00000484767
ENST00000618353
P16591
[Direct mapping] Tyrosine-protein kinase Fer
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000785 [chromatin]
GO:0001932 [regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0010591 [regulation of lamellipodium assembly]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032496 [response to lipopolysaccharide]
GO:0032869 [cellular response to insulin stimulus]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035426 [extracellular matrix-cell signaling]
GO:0035556 [intracellular signal transduction]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0036119 [response to platelet-derived growth factor]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038109 [Kit signaling pathway]
GO:0042058 [regulation of epidermal growth factor receptor signaling pathway]
GO:0042995 [cell projection]
GO:0043304 [regulation of mast cell degranulation]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0050904 [diapedesis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
Show all
 453 aa
51.6 kDa 		No 0

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