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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p11.21
Chromosome location (bp)
32106835 - 32383633
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q96G01 [Direct mapping] Protein bicaudal D homolog 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005881[cytoplasmic microtubule] GO:0006396[RNA processing] GO:0008093[cytoskeletal anchor activity] GO:0008298[intracellular mRNA localization] GO:0009653[anatomical structure morphogenesis] GO:0016020[membrane] GO:0016032[viral process] GO:0019901[protein kinase binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031871[proteinase activated receptor binding] GO:0033365[protein localization to organelle] GO:0034063[stress granule assembly] GO:0034452[dynactin binding] GO:0045505[dynein intermediate chain binding] GO:0048260[positive regulation of receptor-mediated endocytosis] GO:0048471[perinuclear region of cytoplasm] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0070840[dynein complex binding] GO:0072385[minus-end-directed organelle transport along microtubule] GO:0072393[microtubule anchoring at microtubule organizing center] GO:0099503[secretory vesicle] GO:1900275[negative regulation of phospholipase C activity] GO:1900276[regulation of proteinase activated receptor activity] GO:1900737[negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway] GO:1904781[positive regulation of protein localization to centrosome]
Q96G01 [Direct mapping] Protein bicaudal D homolog 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005881[cytoplasmic microtubule] GO:0006396[RNA processing] GO:0008093[cytoskeletal anchor activity] GO:0008298[intracellular mRNA localization] GO:0009653[anatomical structure morphogenesis] GO:0016020[membrane] GO:0016032[viral process] GO:0019901[protein kinase binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031871[proteinase activated receptor binding] GO:0033365[protein localization to organelle] GO:0034063[stress granule assembly] GO:0034452[dynactin binding] GO:0045505[dynein intermediate chain binding] GO:0048260[positive regulation of receptor-mediated endocytosis] GO:0048471[perinuclear region of cytoplasm] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0070840[dynein complex binding] GO:0072385[minus-end-directed organelle transport along microtubule] GO:0072393[microtubule anchoring at microtubule organizing center] GO:0099503[secretory vesicle] GO:1900275[negative regulation of phospholipase C activity] GO:1900276[regulation of proteinase activated receptor activity] GO:1900737[negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway] GO:1904781[positive regulation of protein localization to centrosome]
Q96G01 [Direct mapping] Protein bicaudal D homolog 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200[structural constituent of cytoskeleton] GO:0005515[protein binding] GO:0005794[Golgi apparatus] GO:0005802[trans-Golgi network] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005881[cytoplasmic microtubule] GO:0006396[RNA processing] GO:0008093[cytoskeletal anchor activity] GO:0008298[intracellular mRNA localization] GO:0009653[anatomical structure morphogenesis] GO:0016020[membrane] GO:0016032[viral process] GO:0019901[protein kinase binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031871[proteinase activated receptor binding] GO:0033365[protein localization to organelle] GO:0034063[stress granule assembly] GO:0034452[dynactin binding] GO:0045505[dynein intermediate chain binding] GO:0048260[positive regulation of receptor-mediated endocytosis] GO:0048471[perinuclear region of cytoplasm] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0070840[dynein complex binding] GO:0072385[minus-end-directed organelle transport along microtubule] GO:0072393[microtubule anchoring at microtubule organizing center] GO:0099503[secretory vesicle] GO:1900275[negative regulation of phospholipase C activity] GO:1900276[regulation of proteinase activated receptor activity] GO:1900737[negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway] GO:1904781[positive regulation of protein localization to centrosome]
The Human Protein Atlas project is funded
