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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p22.3
Chromosome location (bp)
33436324 - 33564750
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide exchange factor (GEF) for Ras and Rap1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q8IV61 [Direct mapping] Ras guanyl-releasing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Q8IV61 [Direct mapping] Ras guanyl-releasing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Q8IV61 [Direct mapping] Ras guanyl-releasing protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
C9JWP0 [Direct mapping] Ras guanyl-releasing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005096[GTPase activator activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0043087[regulation of GTPase activity]
C9K0P4 [Direct mapping] Ras guanyl-releasing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005096[GTPase activator activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0043087[regulation of GTPase activity]
C9J9C9 [Direct mapping] Ras guanyl-releasing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005096[GTPase activator activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0043087[regulation of GTPase activity]
C9IYA5 [Direct mapping] Ras guanyl-releasing protein 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005096[GTPase activator activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0043087[regulation of GTPase activity]
The Human Protein Atlas project is funded
