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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q25.3
Chromosome location (bp)
181033374 - 181061938
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells 1,2,3,4,5,6. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers 7,8,9. Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively 10. May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin 11,12. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells 13,14,15. During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome 16. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types 17....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Innate immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q95460 [Direct mapping] Major histocompatibility complex class I-related gene protein
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000139[Golgi membrane] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002854[positive regulation of T cell mediated cytotoxicity directed against tumor cell target] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0019884[antigen processing and presentation of exogenous antigen] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0031902[late endosome membrane] GO:0032393[MHC class I receptor activity] GO:0033077[T cell differentiation in thymus] GO:0042608[T cell receptor binding] GO:0042612[MHC class I protein complex] GO:0045087[innate immune response] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium]
Q95460 [Direct mapping] Major histocompatibility complex class I-related gene protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000139[Golgi membrane] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002854[positive regulation of T cell mediated cytotoxicity directed against tumor cell target] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0019884[antigen processing and presentation of exogenous antigen] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0031902[late endosome membrane] GO:0032393[MHC class I receptor activity] GO:0033077[T cell differentiation in thymus] GO:0042608[T cell receptor binding] GO:0042612[MHC class I protein complex] GO:0045087[innate immune response] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium]
Q95460 [Direct mapping] Major histocompatibility complex class I-related gene protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000139[Golgi membrane] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002854[positive regulation of T cell mediated cytotoxicity directed against tumor cell target] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0019884[antigen processing and presentation of exogenous antigen] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0031902[late endosome membrane] GO:0032393[MHC class I receptor activity] GO:0033077[T cell differentiation in thymus] GO:0042608[T cell receptor binding] GO:0042612[MHC class I protein complex] GO:0045087[innate immune response] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium]
Q95460 [Direct mapping] Major histocompatibility complex class I-related gene protein
Show all
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000139[Golgi membrane] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002854[positive regulation of T cell mediated cytotoxicity directed against tumor cell target] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0019884[antigen processing and presentation of exogenous antigen] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0031902[late endosome membrane] GO:0032393[MHC class I receptor activity] GO:0033077[T cell differentiation in thymus] GO:0042608[T cell receptor binding] GO:0042612[MHC class I protein complex] GO:0045087[innate immune response] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium]
Q95460 [Direct mapping] Major histocompatibility complex class I-related gene protein
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000139[Golgi membrane] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002854[positive regulation of T cell mediated cytotoxicity directed against tumor cell target] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0019884[antigen processing and presentation of exogenous antigen] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0031902[late endosome membrane] GO:0032393[MHC class I receptor activity] GO:0033077[T cell differentiation in thymus] GO:0042608[T cell receptor binding] GO:0042612[MHC class I protein complex] GO:0045087[innate immune response] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium]
The Human Protein Atlas project is funded
