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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q21.1
Chromosome location (bp)
77511753 - 77611834
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Chemotaxis, Inflammatory response
Gene summary (Entrez)i
Useful information about the gene from Entrez
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002467[germinal center formation] GO:0002518[lymphocyte chemotaxis across high endothelial venule] GO:0002544[chronic inflammatory response] GO:0002920[regulation of humoral immune response] GO:0005125[cytokine activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006935[chemotaxis] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007267[cell-cell signaling] GO:0008009[chemokine activity] GO:0008201[heparin binding] GO:0009605[response to external stimulus] GO:0010820[positive regulation of T cell chemotaxis] GO:0017134[fibroblast growth factor binding] GO:0030593[neutrophil chemotaxis] GO:0031724[CXCR5 chemokine receptor binding] GO:0031735[CCR10 chemokine receptor binding] GO:0033625[positive regulation of integrin activation] GO:0033634[positive regulation of cell-cell adhesion mediated by integrin] GO:0035754[B cell chemotaxis] GO:0035768[endothelial cell chemotaxis to fibroblast growth factor] GO:0042742[defense response to bacterium] GO:0045236[CXCR chemokine receptor binding] GO:0045765[regulation of angiogenesis] GO:0048018[receptor ligand activity] GO:0048248[CXCR3 chemokine receptor binding] GO:0060326[cell chemotaxis] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0070098[chemokine-mediated signaling pathway] GO:0071222[cellular response to lipopolysaccharide] GO:0090630[activation of GTPase activity] GO:2000545[negative regulation of endothelial cell chemotaxis to fibroblast growth factor]
The Human Protein Atlas project is funded
