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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q12
Chromosome location (bp)
54657267 - 54740783
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001541[ovarian follicle development] GO:0001650[fibrillar center] GO:0001669[acrosomal vesicle] GO:0002020[protease binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0002318[myeloid progenitor cell differentiation] GO:0002320[lymphoid progenitor cell differentiation] GO:0002327[immature B cell differentiation] GO:0002551[mast cell chemotaxis] GO:0002732[positive regulation of dendritic cell cytokine production] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005020[stem cell factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0006468[protein phosphorylation] GO:0006687[glycosphingolipid metabolic process] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007283[spermatogenesis] GO:0007286[spermatid development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008354[germ cell migration] GO:0008360[regulation of cell shape] GO:0008542[visual learning] GO:0008584[male gonad development] GO:0009314[response to radiation] GO:0009897[external side of plasma membrane] GO:0009898[cytoplasmic side of plasma membrane] GO:0009986[cell surface] GO:0010628[positive regulation of gene expression] GO:0010863[positive regulation of phospholipase C activity] GO:0012501[programmed cell death] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019827[stem cell population maintenance] GO:0019955[cytokine binding] GO:0030032[lamellipodium assembly] GO:0030097[hemopoiesis] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030318[melanocyte differentiation] GO:0030335[positive regulation of cell migration] GO:0031274[positive regulation of pseudopodium assembly] GO:0031401[positive regulation of protein modification process] GO:0031532[actin cytoskeleton reorganization] GO:0032765[positive regulation of mast cell cytokine production] GO:0033674[positive regulation of kinase activity] GO:0035019[somatic stem cell population maintenance] GO:0035162[embryonic hemopoiesis] GO:0035234[ectopic germ cell programmed cell death] GO:0035556[intracellular signal transduction] GO:0035701[hematopoietic stem cell migration] GO:0035855[megakaryocyte development] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0038162[erythropoietin-mediated signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042169[SH2 domain binding] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042803[protein homodimerization activity] GO:0043069[negative regulation of programmed cell death] GO:0043235[receptor complex] GO:0043303[mast cell degranulation] GO:0043406[positive regulation of MAP kinase activity] GO:0043408[regulation of MAPK cascade] GO:0043410[positive regulation of MAPK cascade] GO:0043473[pigmentation] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0043586[tongue development] GO:0045747[positive regulation of Notch signaling pathway] GO:0046427[positive regulation of receptor signaling pathway via JAK-STAT] GO:0046686[response to cadmium ion] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048066[developmental pigmentation] GO:0048103[somatic stem cell division] GO:0048170[positive regulation of long-term neuronal synaptic plasticity] GO:0048565[digestive tract development] GO:0048584[positive regulation of response to stimulus] GO:0048863[stem cell differentiation] GO:0050673[epithelial cell proliferation] GO:0050910[detection of mechanical stimulus involved in sensory perception of sound] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051093[negative regulation of developmental process] GO:0051716[cellular response to stimulus] GO:0060326[cell chemotaxis] GO:0060374[mast cell differentiation] GO:0070662[mast cell proliferation] GO:0070668[positive regulation of mast cell proliferation] GO:0097067[cellular response to thyroid hormone stimulus] GO:0097324[melanocyte migration] GO:0097326[melanocyte adhesion] GO:0120072[positive regulation of pyloric antrum smooth muscle contraction] GO:1904251[regulation of bile acid metabolic process] GO:1904343[positive regulation of colon smooth muscle contraction] GO:1904349[positive regulation of small intestine smooth muscle contraction] GO:1905065[positive regulation of vascular associated smooth muscle cell differentiation] GO:2000242[negative regulation of reproductive process]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001541[ovarian follicle development] GO:0001650[fibrillar center] GO:0002244[hematopoietic progenitor cell differentiation] GO:0002327[immature B cell differentiation] GO:0002551[mast cell chemotaxis] GO:0002732[positive regulation of dendritic cell cytokine production] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007283[spermatogenesis] GO:0008360[regulation of cell shape] GO:0008584[male gonad development] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019827[stem cell population maintenance] GO:0019955[cytokine binding] GO:0030032[lamellipodium assembly] GO:0030097[hemopoiesis] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030318[melanocyte differentiation] GO:0030335[positive regulation of cell migration] GO:0031401[positive regulation of protein modification process] GO:0031532[actin cytoskeleton reorganization] GO:0032765[positive regulation of mast cell cytokine production] GO:0033674[positive regulation of kinase activity] GO:0035162[embryonic hemopoiesis] GO:0035855[megakaryocyte development] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0038162[erythropoietin-mediated signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042803[protein homodimerization activity] GO:0043235[receptor complex] GO:0043303[mast cell degranulation] GO:0043406[positive regulation of MAP kinase activity] GO:0043408[regulation of MAPK cascade] GO:0043410[positive regulation of MAPK cascade] GO:0043473[pigmentation] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0046427[positive regulation of receptor signaling pathway via JAK-STAT] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048565[digestive tract development] GO:0048584[positive regulation of response to stimulus] GO:0048863[stem cell differentiation] GO:0050910[detection of mechanical stimulus involved in sensory perception of sound] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051716[cellular response to stimulus] GO:0060326[cell chemotaxis] GO:0060374[mast cell differentiation] GO:0070662[mast cell proliferation] GO:0097324[melanocyte migration] GO:0097326[melanocyte adhesion] GO:1905065[positive regulation of vascular associated smooth muscle cell differentiation]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the breast and female genital organs Cancers of male genital organs Cancers of haematopoietic and lymphoid tissues Congenital disorders of metabolism Congenital disorders of amino acid metabolism Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019955[cytokine binding] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0038093[Fc receptor signaling pathway] GO:0038109[Kit signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051716[cellular response to stimulus]
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