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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
21
Cytoband
q22.13
Chromosome location (bp)
37365573 - 37526358
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities 1,2,3,4,5. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 6. Plays an important role in double-strand breaks (DSBs) repair following DNA damage 7. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) 8. Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A 9,10. May play a role in a signaling pathway regulating nuclear functions of cell proliferation 11. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0042802[identical protein binding] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0003779[actin binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005883[neurofilament] GO:0005884[actin filament] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008092[cytoskeletal protein binding] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0015631[tubulin binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0042802[identical protein binding] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0003779[actin binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005883[neurofilament] GO:0005884[actin filament] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008092[cytoskeletal protein binding] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0015631[tubulin binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0003779[actin binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005883[neurofilament] GO:0005884[actin filament] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008092[cytoskeletal protein binding] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0015631[tubulin binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0042802[identical protein binding] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048025[negative regulation of mRNA splicing, via spliceosome] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)] GO:1990904[ribonucleoprotein complex]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0003713[transcription coactivator activity] GO:0003779[actin binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005883[neurofilament] GO:0005884[actin filament] GO:0006468[protein phosphorylation] GO:0007399[nervous system development] GO:0007623[circadian rhythm] GO:0008092[cytoskeletal protein binding] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0015631[tubulin binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030424[axon] GO:0030425[dendrite] GO:0031115[negative regulation of microtubule polymerization] GO:0033120[positive regulation of RNA splicing] GO:0034205[amyloid-beta formation] GO:0036289[peptidyl-serine autophosphorylation] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043621[protein self-association] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0050321[tau-protein kinase activity] GO:0090310[negative regulation of DNA methylation-dependent heterochromatin formation] GO:0090312[positive regulation of protein deacetylation] GO:0106310[protein serine kinase activity] GO:0140857[histone kinase activity (H3-T45 specific)]
MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
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