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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q22.3
Chromosome location (bp)
136862208 - 136951606
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Translation regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000164[protein phosphatase type 1 complex] GO:0004860[protein kinase inhibitor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005840[ribosome] GO:0005886[plasma membrane] GO:0006417[regulation of translation] GO:0007165[signal transduction] GO:0007172[signal complex assembly] GO:0008093[cytoskeletal anchor activity] GO:0016477[cell migration] GO:0030159[signaling receptor complex adaptor activity] GO:0030674[protein-macromolecule adaptor activity] GO:0030838[positive regulation of actin filament polymerization] GO:0030971[receptor tyrosine kinase binding] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0035591[signaling adaptor activity] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042102[positive regulation of T cell proliferation] GO:0042110[T cell activation] GO:0045296[cadherin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046875[ephrin receptor binding] GO:0060548[negative regulation of cell death] GO:0070262[peptidyl-serine dephosphorylation] GO:0071074[eukaryotic initiation factor eIF2 binding] GO:0140693[molecular condensate scaffold activity] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903676[positive regulation of cap-dependent translational initiation] GO:1903679[positive regulation of cap-independent translational initiation] GO:1903898[negative regulation of PERK-mediated unfolded protein response] GO:1903912[negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation] GO:1990441[negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000164[protein phosphatase type 1 complex] GO:0004860[protein kinase inhibitor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005840[ribosome] GO:0005886[plasma membrane] GO:0006417[regulation of translation] GO:0007165[signal transduction] GO:0007172[signal complex assembly] GO:0008093[cytoskeletal anchor activity] GO:0016477[cell migration] GO:0030159[signaling receptor complex adaptor activity] GO:0030674[protein-macromolecule adaptor activity] GO:0030838[positive regulation of actin filament polymerization] GO:0030971[receptor tyrosine kinase binding] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0035591[signaling adaptor activity] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042102[positive regulation of T cell proliferation] GO:0042110[T cell activation] GO:0045296[cadherin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046875[ephrin receptor binding] GO:0060548[negative regulation of cell death] GO:0070262[peptidyl-serine dephosphorylation] GO:0071074[eukaryotic initiation factor eIF2 binding] GO:0140693[molecular condensate scaffold activity] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903676[positive regulation of cap-dependent translational initiation] GO:1903679[positive regulation of cap-independent translational initiation] GO:1903898[negative regulation of PERK-mediated unfolded protein response] GO:1903912[negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation] GO:1990441[negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164[protein phosphatase type 1 complex] GO:0004860[protein kinase inhibitor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0005840[ribosome] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0006417[regulation of translation] GO:0006930[substrate-dependent cell migration, cell extension] GO:0007015[actin filament organization] GO:0007165[signal transduction] GO:0007172[signal complex assembly] GO:0008093[cytoskeletal anchor activity] GO:0010976[positive regulation of neuron projection development] GO:0012506[vesicle membrane] GO:0016477[cell migration] GO:0019904[protein domain specific binding] GO:0030032[lamellipodium assembly] GO:0030159[signaling receptor complex adaptor activity] GO:0030334[regulation of cell migration] GO:0030674[protein-macromolecule adaptor activity] GO:0030838[positive regulation of actin filament polymerization] GO:0030971[receptor tyrosine kinase binding] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0035591[signaling adaptor activity] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042102[positive regulation of T cell proliferation] GO:0042110[T cell activation] GO:0045296[cadherin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046875[ephrin receptor binding] GO:0048013[ephrin receptor signaling pathway] GO:0051707[response to other organism] GO:0060548[negative regulation of cell death] GO:0070262[peptidyl-serine dephosphorylation] GO:0071074[eukaryotic initiation factor eIF2 binding] GO:0140693[molecular condensate scaffold activity] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903676[positive regulation of cap-dependent translational initiation] GO:1903679[positive regulation of cap-independent translational initiation] GO:1903898[negative regulation of PERK-mediated unfolded protein response] GO:1903912[negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation] GO:1990441[negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
The Human Protein Atlas project is funded
