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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Human disease related genes Metabolic proteins Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q23.3
Chromosome location (bp)
161222292 - 161223631
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Lipid transport, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Metabolic proteins Transporters Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002526[acute inflammatory response] GO:0002719[negative regulation of cytokine production involved in immune response] GO:0005102[signaling receptor binding] GO:0005319[lipid transporter activity] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005769[early endosome] GO:0005788[endoplasmic reticulum lumen] GO:0005829[cytosol] GO:0006641[triglyceride metabolic process] GO:0006656[phosphatidylcholine biosynthetic process] GO:0006869[lipid transport] GO:0008035[high-density lipoprotein particle binding] GO:0008203[cholesterol metabolic process] GO:0008289[lipid binding] GO:0009395[phospholipid catabolic process] GO:0009410[response to xenobiotic stimulus] GO:0009749[response to glucose] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0015485[cholesterol binding] GO:0018158[protein oxidation] GO:0018206[peptidyl-methionine modification] GO:0019899[enzyme binding] GO:0030300[regulation of intestinal cholesterol absorption] GO:0030301[cholesterol transport] GO:0031072[heat shock protein binding] GO:0031100[animal organ regeneration] GO:0031210[phosphatidylcholine binding] GO:0031647[regulation of protein stability] GO:0032375[negative regulation of cholesterol transport] GO:0032757[positive regulation of interleukin-8 production] GO:0033344[cholesterol efflux] GO:0033700[phospholipid efflux] GO:0034190[apolipoprotein receptor binding] GO:0034361[very-low-density lipoprotein particle] GO:0034364[high-density lipoprotein particle] GO:0034366[spherical high-density lipoprotein particle] GO:0034370[triglyceride-rich lipoprotein particle remodeling] GO:0034374[low-density lipoprotein particle remodeling] GO:0034375[high-density lipoprotein particle remodeling] GO:0034380[high-density lipoprotein particle assembly] GO:0034384[high-density lipoprotein particle clearance] GO:0042157[lipoprotein metabolic process] GO:0042627[chylomicron] GO:0042632[cholesterol homeostasis] GO:0042803[protein homodimerization activity] GO:0043627[response to estrogen] GO:0043691[reverse cholesterol transport] GO:0046340[diacylglycerol catabolic process] GO:0046982[protein heterodimerization activity] GO:0050766[positive regulation of phagocytosis] GO:0050821[protein stabilization] GO:0050995[negative regulation of lipid catabolic process] GO:0050996[positive regulation of lipid catabolic process] GO:0051384[response to glucocorticoid] GO:0055102[lipase inhibitor activity] GO:0060192[negative regulation of lipase activity] GO:0060228[phosphatidylcholine-sterol O-acyltransferase activator activity] GO:0060621[negative regulation of cholesterol import] GO:0060695[negative regulation of cholesterol transporter activity] GO:0070062[extracellular exosome] GO:0070653[high-density lipoprotein particle receptor binding] GO:0072562[blood microparticle] GO:0120009[intermembrane lipid transfer] GO:0120020[cholesterol transfer activity] GO:1905920[positive regulation of CoA-transferase activity]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
