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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p21.2
Chromosome location (bp)
23841929 - 23854806
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hormone
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001503[ossification] GO:0001886[endothelial cell morphogenesis] GO:0003421[growth plate cartilage axis specification] GO:0005179[hormone activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006874[cellular calcium ion homeostasis] GO:0007165[signal transduction] GO:0007566[embryo implantation] GO:0010596[negative regulation of endothelial cell migration] GO:0014070[response to organic cyclic compound] GO:0016324[apical plasma membrane] GO:0030336[negative regulation of cell migration] GO:0033280[response to vitamin D] GO:0035988[chondrocyte proliferation] GO:0042802[identical protein binding] GO:0044070[regulation of anion transport] GO:0046697[decidualization] GO:0051926[negative regulation of calcium ion transport] GO:0060348[bone development] GO:0071320[cellular response to cAMP] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071456[cellular response to hypoxia] GO:0086004[regulation of cardiac muscle cell contraction] GO:0090280[positive regulation of calcium ion import] GO:1903403[negative regulation of renal phosphate excretion]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001886[endothelial cell morphogenesis] GO:0003421[growth plate cartilage axis specification] GO:0005179[hormone activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006874[cellular calcium ion homeostasis] GO:0007165[signal transduction] GO:0010596[negative regulation of endothelial cell migration] GO:0030336[negative regulation of cell migration] GO:0035988[chondrocyte proliferation] GO:0042802[identical protein binding] GO:0044070[regulation of anion transport] GO:0051926[negative regulation of calcium ion transport] GO:0060348[bone development] GO:0086004[regulation of cardiac muscle cell contraction] GO:0090280[positive regulation of calcium ion import] GO:1903403[negative regulation of renal phosphate excretion]
The Human Protein Atlas project is funded
