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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q34.2
Chromosome location (bp)
133761894 - 133992604
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005154[epidermal growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008361[regulation of cell size] GO:0016477[cell migration] GO:0030031[cell projection assembly] GO:0030032[lamellipodium assembly] GO:0030168[platelet activation] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043087[regulation of GTPase activity] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0071466[cellular response to xenobiotic stimulus]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007165[signal transduction] GO:0008361[regulation of cell size] GO:0016477[cell migration] GO:0030168[platelet activation] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043087[regulation of GTPase activity] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0071466[cellular response to xenobiotic stimulus]
Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007165[signal transduction] GO:0008361[regulation of cell size] GO:0016477[cell migration] GO:0030168[platelet activation] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043087[regulation of GTPase activity] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0071466[cellular response to xenobiotic stimulus]
The Human Protein Atlas project is funded
