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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q11.2
Chromosome location (bp)
29390363 - 29551903
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system 1. Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, DNA damage, DNA repair
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of JNK cascade. Located in microtubule cytoskeleton and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A0A024QZ70 [Target identity:100%; Query identity:100%] TAO kinase 1, isoform CRA_a
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0000226[microtubule cytoskeleton organization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007026[negative regulation of microtubule depolymerization] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0015630[microtubule cytoskeleton] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0021954[central nervous system neuron development] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0032956[regulation of actin cytoskeleton organization] GO:0035556[intracellular signal transduction] GO:0043014[alpha-tubulin binding] GO:0043408[regulation of MAPK cascade] GO:0043539[protein serine/threonine kinase activator activity] GO:0046330[positive regulation of JNK cascade] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0048471[perinuclear region of cytoplasm] GO:0048487[beta-tubulin binding] GO:0048812[neuron projection morphogenesis] GO:0050321[tau-protein kinase activity] GO:0051493[regulation of cytoskeleton organization] GO:0070050[neuron cellular homeostasis] GO:0070062[extracellular exosome] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0097194[execution phase of apoptosis] GO:0106310[protein serine kinase activity] GO:1901985[positive regulation of protein acetylation]
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0000226[microtubule cytoskeleton organization] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007026[negative regulation of microtubule depolymerization] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0015630[microtubule cytoskeleton] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0021954[central nervous system neuron development] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0032956[regulation of actin cytoskeleton organization] GO:0035556[intracellular signal transduction] GO:0043014[alpha-tubulin binding] GO:0043408[regulation of MAPK cascade] GO:0043539[protein serine/threonine kinase activator activity] GO:0046330[positive regulation of JNK cascade] GO:0046777[protein autophosphorylation] GO:0048156[tau protein binding] GO:0048471[perinuclear region of cytoplasm] GO:0048487[beta-tubulin binding] GO:0048812[neuron projection morphogenesis] GO:0050321[tau-protein kinase activity] GO:0051493[regulation of cytoskeleton organization] GO:0070050[neuron cellular homeostasis] GO:0070062[extracellular exosome] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0097194[execution phase of apoptosis] GO:0106310[protein serine kinase activity] GO:1901985[positive regulation of protein acetylation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
