Expression of RPL8 in testis cancer - The Human Protein Atlas

TESTIS CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPL8 is not prognostic in testis cancer

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1923.34

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

1526.1

Number of samples

134

Samples

Sample	Description	FPKM
TCGA-2G-AAFN-01A	26 years, male, white, stage:iiib, alive, 773 days	4653.2
TCGA-2G-AAL7-01A	32 years, male, white, stage:is, alive, 3991 days	3791.5
TCGA-2G-AAFM-01A	31 years, male, white, stage:iia, alive, 503 days	3413.5
TCGA-2G-AAHP-01A	31 years, male, white, stage:is, alive, 5667 days	3118.7
TCGA-VF-A8A8-01A	18 years, male, white, stage:ia, alive, 1131 days	3073.5
TCGA-W4-A7U4-01A	23 years, male, white, alive, 738 days	3007.1
TCGA-2G-AAKL-01A	26 years, male, white, stage:ii, alive, 7023 days	2932.9
TCGA-2G-AAKG-01A	22 years, male, white, stage:i, alive, 6598 days	2895.3
TCGA-2G-AAHL-01A	26 years, male, white, stage:i, alive, 7081 days	2807.0
TCGA-XE-AANR-01A	24 years, male, white, stage:i, alive, 14 days	2800.9
TCGA-2G-AAGW-01A	38 years, male, white, stage:is, alive, 4899 days	2708.1
TCGA-WZ-A8D5-01A	38 years, male, white, alive, 774 days	2649.2
TCGA-SB-A6J6-01A	22 years, male, white, stage:ia, alive, 413 days	2611.7
TCGA-4K-AAAL-01A	31 years, male, white, stage:is, alive, 483 days	2606.6
TCGA-2G-AAEX-01A	38 years, male, white, stage:is, alive, 1259 days	2499.4
TCGA-SN-A84Y-01A	18 years, male, white, stage:is, alive, 524 days	2482.8
TCGA-2G-AAFI-01A	41 years, male, white, stage:ib, alive, 675 days	2464.9
TCGA-VF-A8AE-01A	39 years, male, white, stage:ia, alive, 727 days	2459.3
TCGA-2G-AAGA-01A	38 years, male, white, stage:iia, alive, 2439 days	2413.1
TCGA-2G-AAGZ-01A	27 years, male, white, stage:iiia, alive, 5233 days	2389.4
TCGA-SN-A84X-01A	21 years, male, white, stage:is, alive, 312 days	2285.8
TCGA-2G-AAGN-01A	41 years, male, white, stage:iiib, alive, 3656 days	2284.0
TCGA-4K-AA1I-01A	26 years, male, white, stage:ia, alive, 3 days	2223.0
TCGA-2G-AAG8-01A	21 years, male, white, stage:ib, alive, 2289 days	2150.8
TCGA-2G-AAGO-01A	41 years, male, white, stage:is, alive, 4026 days	2124.1
TCGA-WZ-A7V3-01A	20 years, male, white, stage:i, alive, 753 days	2058.3
TCGA-2G-AAFO-01A	33 years, male, white, stage:iia, alive, 685 days	2039.0
TCGA-2G-AAFL-01A	35 years, male, white, stage:ib, alive, 750 days	2024.0
TCGA-XE-A8H1-01A	24 years, male, white, stage:is, alive, 209 days	2020.0
TCGA-2G-AAGC-01A	28 years, male, white, stage:is, alive, 2585 days	1981.5
TCGA-S6-A8JX-01A	27 years, male, white, stage:ib, alive, 552 days	1980.8
TCGA-YU-A90W-01A	45 years, male, white, stage:ia, alive, 1113 days	1978.3
TCGA-2G-AAGF-01A	28 years, male, white, stage:is, alive, 2734 days	1924.7
TCGA-YU-A90Y-01A	23 years, male, black or african american, stage:iiic, dead, 17 days	1922.0
TCGA-VF-A8AD-01A	36 years, male, white, stage:ib, alive, 1006 days	1876.7
TCGA-XE-AANJ-01A	39 years, male, white, stage:is, alive, 2007 days	1869.4
TCGA-ZM-AA06-01A	45 years, male, white, stage:ib, alive, 1498 days	1845.5
TCGA-2G-AAFY-01A	24 years, male, white, stage:iia, alive, 1099 days	1844.9
TCGA-SN-A6IS-01A	26 years, male, white, stage:is, alive, 496 days	1804.5
TCGA-2G-AAH8-01A	45 years, male, white, stage:iiic, alive, 2248 days	1792.8
TCGA-2G-AAGE-01A	21 years, male, white, stage:is, alive, 2478 days	1774.1
TCGA-2G-AAKD-01A	18 years, male, white, stage:iii, alive, 6340 days	1770.6
TCGA-XY-A9T9-01A	37 years, male, white, stage:is, alive, 281 days	1762.4
TCGA-SB-A76C-01A	38 years, male, white, alive, 42 days	1730.8
TCGA-XY-A8S2-01A	67 years, male, white, stage:i, alive, 672 days	1719.2
TCGA-2G-AAHG-01A	25 years, male, white, stage:i, alive, 1819 days	1702.5
TCGA-WZ-A7V5-01A	27 years, male, white, stage:i, alive, 1061 days	1667.4
TCGA-2G-AALP-01A	43 years, male, white, stage:iiib, alive, 2645 days	1662.1
TCGA-2G-AAG3-01A	53 years, male, white, stage:is, alive, 1593 days	1632.0
TCGA-2G-AAFG-01A	30 years, male, white, stage:is, alive, 6183 days	1628.9
TCGA-XE-A8H5-01A	29 years, male, stage:is, alive, 1217 days	1608.0
TCGA-2G-AAF4-01A	30 years, male, white, stage:i, alive, 2315 days	1601.6
TCGA-XE-AAO3-01A	33 years, male, asian, stage:i, alive, 2857 days	1580.7
TCGA-XE-AAOD-01A	39 years, male, white, stage:ib, alive, 2058 days	1574.9
TCGA-XE-AAOF-01A	50 years, male, asian, stage:ia, alive, 1268 days	1574.2
TCGA-2G-AAGJ-01A	28 years, male, black or african american, stage:ia, alive, 2938 days	1552.0
TCGA-ZM-AA0B-01A	32 years, male, white, stage:ia, alive, 838 days	1542.3
TCGA-XY-A8S3-01B	24 years, male, white, stage:is, alive, 843 days	1497.4
TCGA-ZM-AA0N-01A	44 years, male, white, stage:ib, alive, 634 days	1476.6
TCGA-2G-AAKM-01A	14 years, male, white, stage:ii, dead, 6972 days	1454.8
TCGA-ZM-AA0E-01A	39 years, male, white, stage:ia, alive, 811 days	1445.7
TCGA-XE-A9SE-01A	35 years, male, white, stage:ia, alive, 708 days	1431.4
TCGA-2G-AAHC-01A	33 years, male, white, stage:is, alive, 5539 days	1425.8
TCGA-S6-A8JY-01A	27 years, male, white, stage:is, alive, 278 days	1411.0
TCGA-2G-AAH3-01A	20 years, male, white, stage:i, alive, 1822 days	1410.7
TCGA-VF-A8AC-01A	29 years, male, white, stage:ia, alive, 1083 days	1396.3
TCGA-VF-A8A9-01A	31 years, male, white, stage:ia, alive, 1119 days	1390.5
TCGA-2X-A9D5-01A	49 years, male, white, stage:i, alive, 435 days	1365.7
TCGA-YU-A912-01A	34 years, male, black or african american, stage:iiic, alive, 866 days	1357.1
TCGA-XE-A8H4-01A	23 years, male, white, stage:ia, alive, 559 days	1356.6
TCGA-XE-AAO4-01A	40 years, male, white, stage:ia, alive, 367 days	1352.9
TCGA-YU-A90P-01A	25 years, male, white, stage:ia, alive, 2069 days	1347.5
TCGA-2G-AAKH-01A	19 years, male, white, stage:ii, alive, 6862 days	1343.3
TCGA-W4-A7U2-01A	26 years, male, white, alive, 1263 days	1338.5
TCGA-2G-AAH0-01A	30 years, male, white, stage:is, alive, 5477 days	1322.0
TCGA-YU-AA61-01A	29 years, male, white, stage:is, alive, 864 days	1311.4
TCGA-2G-AAGK-01A	20 years, male, white, stage:is, alive, 3621 days	1307.7
TCGA-2G-AAGS-01A	39 years, male, white, stage:iiib, alive, 4816 days	1304.8
TCGA-2G-AAG0-01A	23 years, male, white, stage:is, alive, 1529 days	1300.1
TCGA-2G-AAFE-01A	37 years, male, white, stage:iia, alive, 4702 days	1290.1
TCGA-YU-A94D-01A	28 years, male, stage:iiib, alive, 2167 days	1279.3
TCGA-SO-A8JP-01A	29 years, male, white, stage:i, alive, 540 days	1234.7
TCGA-VF-A8AA-01A	51 years, male, white, stage:i, alive, 1146 days	1215.9
TCGA-2G-AAHN-01A	32 years, male, white, stage:i, alive, 6445 days	1213.5
TCGA-2G-AAF8-01A	33 years, male, white, stage:ia, alive, 3911 days	1212.7
TCGA-XE-AAO6-01A	47 years, male, white, stage:ia, alive, 240 days	1206.8
TCGA-X3-A8G4-01A	33 years, male, white, stage:is, alive, 856 days	1206.6
TCGA-2G-AAF6-01A	28 years, male, white, stage:is, alive, 3491 days	1205.7
TCGA-XE-AANV-01A	52 years, male, stage:ib, alive, 1701 days	1190.7
TCGA-2G-AAFH-01A	38 years, male, white, stage:iib, alive, 1375 days	1178.9
TCGA-2G-AAG9-01A	25 years, male, white, stage:iiib, alive, 2234 days	1156.7
TCGA-S6-A8JW-01A	37 years, male, white, stage:is, alive, 698 days	1136.3
TCGA-2G-AAH4-01A	34 years, male, white, stage:ii, alive, 6210 days	1094.5
TCGA-2G-AAH2-01A	20 years, male, white, stage:is, alive, 6060 days	1075.2
TCGA-YU-A90Q-01A	21 years, male, stage:ib, alive, 1964 days	1053.2
TCGA-2G-AAHT-01A	32 years, male, white, stage:is, alive, 542 days	1027.9
TCGA-XE-AAOJ-01A	24 years, male, white, stage:is, alive, 1550 days	1026.7
TCGA-2G-AAEW-01A	31 years, male, white, stage:is, dead, 618 days	1013.5
TCGA-ZM-AA0H-01A	50 years, male, white, stage:is, alive, 1736 days	1012.4
TCGA-VF-A8AB-01A	31 years, male, black or african american, stage:ia, alive, 760 days	1002.3
TCGA-XE-AAOL-01A	38 years, male, black or african american, stage:i, alive, 13 days	1001.3
TCGA-XY-A89B-01A	35 years, male, white, stage:ia, alive, 471 days	998.6
TCGA-2G-AAFZ-01A	32 years, male, white, stage:iii, alive, 1353 days	985.6
TCGA-XE-AAOB-01A	27 years, male, white, stage:is, dead, 513 days	984.6
TCGA-WZ-A7V4-01A	28 years, male, white, stage:i, alive, 894 days	971.1
TCGA-ZM-AA0D-01A	34 years, male, white, stage:ia, alive, 848 days	945.3
TCGA-2G-AAG7-01A	33 years, male, white, stage:is, alive, 2475 days	912.3
TCGA-2G-AAGV-01A	23 years, male, white, alive, 4527 days	890.2
TCGA-ZM-AA0F-01A	35 years, male, white, stage:ia, alive, 681 days	857.5
TCGA-4K-AA1H-01A	26 years, male, white, stage:ia, alive, 518 days	853.7
TCGA-2G-AAF1-01A	28 years, male, asian, stage:is, alive, 1403 days	852.5
TCGA-2G-AAL5-01A	31 years, male, white, stage:i, alive, 7437 days	815.4
TCGA-ZM-AA05-01A	36 years, male, white, stage:iic, alive, 1126 days	807.7
TCGA-2G-AAGM-01A	51 years, male, white, stage:is, alive, 3891 days	807.5
TCGA-2G-AAGX-01A	22 years, male, white, stage:ia, alive, 5514 days	765.7
TCGA-YU-A90S-01A	26 years, male, white, stage:ia, alive, 971 days	747.9
TCGA-2G-AAHA-01A	48 years, male, white, stage:ib, alive, 3349 days	743.8
TCGA-2G-AAGT-01A	30 years, male, white, stage:is, alive, 4406 days	703.2
TCGA-YU-AA4L-01A	27 years, male, black or african american, stage:iiic, alive, 1573 days	701.3
TCGA-2G-AAGI-01A	33 years, male, white, stage:is, alive, 3137 days	666.2
TCGA-4K-AA1G-01A	34 years, male, white, stage:is, alive, 436 days	663.6
TCGA-2G-AAG6-01A	24 years, male, white, stage:is, alive, 2231 days	655.2
TCGA-2G-AAGP-01A	33 years, male, white, stage:iia, alive, 4018 days	643.2
TCGA-2G-AAFV-01A	31 years, male, white, stage:is, alive, 1389 days	582.5
TCGA-2G-AAGG-01A	20 years, male, white, stage:iiic, alive, 2611 days	558.3
TCGA-2X-A9D6-01A	42 years, male, white, stage:i, alive, 607 days	544.9
TCGA-2G-AAG5-01A	36 years, male, white, stage:is, alive, 2299 days	524.2
TCGA-W4-A7U3-01A	26 years, male, white, alive, 149 days	500.8
TCGA-SN-A84W-01A	30 years, male, white, stage:is, alive, 293 days	492.3
TCGA-YU-A94I-01A	66 years, male, stage:ia, alive, 536 days	447.5
TCGA-XE-AAOC-01A	31 years, male, white, stage:ia, alive, 270 days	445.5
TCGA-2G-AAFJ-01A	23 years, male, asian, alive, 792 days	442.7
TCGA-2G-AAGY-01A	28 years, male, white, stage:is, alive, 5329 days	374.9
TCGA-XE-AANI-01A	37 years, male, white, stage:is, alive, 1041 days	339.1
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TESTIS CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA045095	Antibody HPA050165
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details