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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.13
Chromosome location (bp)
54369133 - 54391298
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'- UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, Transcription, Transcription regulation, Translation regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004).[supplied by OMIM, Oct 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0002039[p53 binding] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0008270[zinc ion binding] GO:0010609[mRNA localization resulting in post-transcriptional regulation of gene expression] GO:0030425[dendrite] GO:0035855[megakaryocyte development] GO:0042995[cell projection] GO:0043025[neuronal cell body] GO:0045600[positive regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000765[regulation of cytoplasmic translation]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0002039[p53 binding] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0008270[zinc ion binding] GO:0010609[mRNA localization resulting in post-transcriptional regulation of gene expression] GO:0030425[dendrite] GO:0035855[megakaryocyte development] GO:0042995[cell projection] GO:0043025[neuronal cell body] GO:0045600[positive regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000765[regulation of cytoplasmic translation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0002039[p53 binding] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007599[hemostasis] GO:0007611[learning or memory] GO:0007626[locomotory behavior] GO:0008270[zinc ion binding] GO:0008298[intracellular mRNA localization] GO:0010609[mRNA localization resulting in post-transcriptional regulation of gene expression] GO:0030220[platelet formation] GO:0030425[dendrite] GO:0035855[megakaryocyte development] GO:0042995[cell projection] GO:0043025[neuronal cell body] GO:0045600[positive regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:0070889[platelet alpha granule organization] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000765[regulation of cytoplasmic translation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0002039[p53 binding] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0008270[zinc ion binding] GO:0010609[mRNA localization resulting in post-transcriptional regulation of gene expression] GO:0030425[dendrite] GO:0035855[megakaryocyte development] GO:0042995[cell projection] GO:0043025[neuronal cell body] GO:0045600[positive regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000765[regulation of cytoplasmic translation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0002039[p53 binding] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0008270[zinc ion binding] GO:0010609[mRNA localization resulting in post-transcriptional regulation of gene expression] GO:0030425[dendrite] GO:0035855[megakaryocyte development] GO:0042995[cell projection] GO:0043025[neuronal cell body] GO:0045600[positive regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000765[regulation of cytoplasmic translation]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0002039[p53 binding] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0008270[zinc ion binding] GO:0010609[mRNA localization resulting in post-transcriptional regulation of gene expression] GO:0030425[dendrite] GO:0035855[megakaryocyte development] GO:0042995[cell projection] GO:0043025[neuronal cell body] GO:0045600[positive regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:1902164[positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000765[regulation of cytoplasmic translation]
The Human Protein Atlas project is funded
