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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q32.1
Chromosome location (bp)
183078559 - 183100008
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q8WTR2 [Direct mapping] Dual specificity protein phosphatase 19
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004860[protein kinase inhibitor activity] GO:0005078[MAP-kinase scaffold activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0006470[protein dephosphorylation] GO:0008138[protein tyrosine/serine/threonine phosphatase activity] GO:0008579[JUN kinase phosphatase activity] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017018[myosin phosphatase activity] GO:0030295[protein kinase activator activity] GO:0031435[mitogen-activated protein kinase kinase kinase binding] GO:0043405[regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043507[positive regulation of JUN kinase activity] GO:0043508[negative regulation of JUN kinase activity] GO:0045860[positive regulation of protein kinase activity] GO:0046329[negative regulation of JNK cascade] GO:0046330[positive regulation of JNK cascade]
Q8WTR2 [Direct mapping] Dual specificity protein phosphatase 19
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Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004860[protein kinase inhibitor activity] GO:0005078[MAP-kinase scaffold activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0006470[protein dephosphorylation] GO:0008138[protein tyrosine/serine/threonine phosphatase activity] GO:0008579[JUN kinase phosphatase activity] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017018[myosin phosphatase activity] GO:0030295[protein kinase activator activity] GO:0031435[mitogen-activated protein kinase kinase kinase binding] GO:0043405[regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043507[positive regulation of JUN kinase activity] GO:0043508[negative regulation of JUN kinase activity] GO:0045860[positive regulation of protein kinase activity] GO:0046329[negative regulation of JNK cascade] GO:0046330[positive regulation of JNK cascade]
The Human Protein Atlas project is funded
