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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q26.2
Chromosome location (bp)
170222424 - 170305977
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P41743 [Direct mapping] Protein kinase C iota type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005543[phospholipid binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005903[brush border] GO:0005923[bicellular tight junction] GO:0006468[protein phosphorylation] GO:0006612[protein targeting to membrane] GO:0007010[cytoskeleton organization] GO:0007015[actin filament organization] GO:0008104[protein localization] GO:0010976[positive regulation of neuron projection development] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016192[vesicle-mediated transport] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016324[apical plasma membrane] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0031252[cell leading edge] GO:0032869[cellular response to insulin stimulus] GO:0034351[negative regulation of glial cell apoptotic process] GO:0035089[establishment of apical/basal cell polarity] GO:0035556[intracellular signal transduction] GO:0042462[eye photoreceptor cell development] GO:0043066[negative regulation of apoptotic process] GO:0043220[Schmidt-Lanterman incisure] GO:0043434[response to peptide hormone] GO:0043524[negative regulation of neuron apoptotic process] GO:0045171[intercellular bridge] GO:0045177[apical part of cell] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045216[cell-cell junction organization] GO:0045747[positive regulation of Notch signaling pathway] GO:0046326[positive regulation of glucose import] GO:0046872[metal ion binding] GO:0046903[secretion] GO:0048194[Golgi vesicle budding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060252[positive regulation of glial cell proliferation] GO:0061024[membrane organization] GO:0070062[extracellular exosome] GO:0070160[tight junction] GO:0070555[response to interleukin-1] GO:0098685[Schaffer collateral - CA1 synapse] GO:0098978[glutamatergic synapse] GO:0099072[regulation of postsynaptic membrane neurotransmitter receptor levels] GO:0106310[protein serine kinase activity] GO:0120157[PAR polarity complex] GO:1903078[positive regulation of protein localization to plasma membrane] GO:2000353[positive regulation of endothelial cell apoptotic process]
The Human Protein Atlas project is funded
