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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Disease related genes FDA approved drug targets Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q33.2
Chromosome location (bp)
203853888 - 203873965
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Adaptive immunity, Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P16410 [Direct mapping] Cytotoxic T-lymphocyte protein 4
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CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Other immune system diseases Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0030889[negative regulation of B cell proliferation] GO:0042129[regulation of T cell proliferation] GO:0043065[positive regulation of apoptotic process] GO:0045334[clathrin-coated endocytic vesicle] GO:0045590[negative regulation of regulatory T cell differentiation] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050853[B cell receptor signaling pathway] GO:0098636[protein complex involved in cell adhesion] GO:0110165[cellular anatomical entity]
P16410 [Direct mapping] Cytotoxic T-lymphocyte protein 4
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CD markers MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Other immune system diseases Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0030889[negative regulation of B cell proliferation] GO:0042129[regulation of T cell proliferation] GO:0043065[positive regulation of apoptotic process] GO:0045334[clathrin-coated endocytic vesicle] GO:0045590[negative regulation of regulatory T cell differentiation] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050853[B cell receptor signaling pathway] GO:0098636[protein complex involved in cell adhesion] GO:0110165[cellular anatomical entity]
P16410 [Direct mapping] Cytotoxic T-lymphocyte protein 4
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Other immune system diseases Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0006974[cellular response to DNA damage stimulus] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0030889[negative regulation of B cell proliferation] GO:0042129[regulation of T cell proliferation] GO:0042130[negative regulation of T cell proliferation] GO:0043065[positive regulation of apoptotic process] GO:0045334[clathrin-coated endocytic vesicle] GO:0045590[negative regulation of regulatory T cell differentiation] GO:0048471[perinuclear region of cytoplasm] GO:0050777[negative regulation of immune response] GO:0050852[T cell receptor signaling pathway] GO:0050853[B cell receptor signaling pathway] GO:0098636[protein complex involved in cell adhesion] GO:0110165[cellular anatomical entity]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Human disease related genes Digestive system diseases Gastrointestinal diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Other immune system diseases Nervous system diseases Other nervous and sensory system diseases
The Human Protein Atlas project is funded
