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DACT2 RNA transcripts are highly distributed in placenta, in moderate levels in brain and lower in the rest of human organs. In mouse brain, available transcriptomic and proteomic data agree on an enrichment across cortical areas, demonstrating a predominantly dendritic/synaptic staining pattern.
Indeed, moderate-intensity diffuse/synaptic-type immunoreactivity is noticed throughout the entire forebrain. In the brainstem, this patterns is rather restricted to certain gray matter areas, like the periaqueductal gray matter, dorsal raphe, substantia nigra, dorsal part of medulla around the fourth ventricle.
In addition, moderate-strong somato-dendritic immunostaining of neurons is noticed in the lateral septum, nucleus accumbens, cerebellar Purkinje-cells and in multiple brainstem nuclei.
In addition, distinct strong axonal immunostaining is noticed in the olfactory bulb glomerular- and external plexiform layers.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
The Human Protein Atlas project is funded
