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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q22.2
Chromosome location (bp)
98944403 - 98952104
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004).[supplied by OMIM, Mar 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q8N2R0 [Direct mapping] Protein odd-skipped-related 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001655[urogenital system development] GO:0001656[metanephros development] GO:0001823[mesonephros development] GO:0002062[chondrocyte differentiation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009792[embryo development ending in birth or egg hatching] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030501[positive regulation of bone mineralization] GO:0033687[osteoblast proliferation] GO:0035115[embryonic forelimb morphogenesis] GO:0035116[embryonic hindlimb morphogenesis] GO:0036023[embryonic skeletal limb joint morphogenesis] GO:0042474[middle ear morphogenesis] GO:0042476[odontogenesis] GO:0042733[embryonic digit morphogenesis] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048704[embryonic skeletal system morphogenesis] GO:0050679[positive regulation of epithelial cell proliferation] GO:0060021[roof of mouth development] GO:0060272[embryonic skeletal joint morphogenesis] GO:0060322[head development] GO:0060349[bone morphogenesis] GO:0061029[eyelid development in camera-type eye] GO:0072089[stem cell proliferation] GO:0072498[embryonic skeletal joint development] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000648[positive regulation of stem cell proliferation]
Q8N2R0 [Direct mapping] Protein odd-skipped-related 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001655[urogenital system development] GO:0001656[metanephros development] GO:0001823[mesonephros development] GO:0002062[chondrocyte differentiation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008284[positive regulation of cell population proliferation] GO:0009792[embryo development ending in birth or egg hatching] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030501[positive regulation of bone mineralization] GO:0033687[osteoblast proliferation] GO:0035115[embryonic forelimb morphogenesis] GO:0035116[embryonic hindlimb morphogenesis] GO:0036023[embryonic skeletal limb joint morphogenesis] GO:0042474[middle ear morphogenesis] GO:0042476[odontogenesis] GO:0042733[embryonic digit morphogenesis] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048704[embryonic skeletal system morphogenesis] GO:0050679[positive regulation of epithelial cell proliferation] GO:0060021[roof of mouth development] GO:0060272[embryonic skeletal joint morphogenesis] GO:0060322[head development] GO:0060349[bone morphogenesis] GO:0061029[eyelid development in camera-type eye] GO:0072498[embryonic skeletal joint development] GO:1990837[sequence-specific double-stranded DNA binding]
Q8N2R0 [Direct mapping] Protein odd-skipped-related 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001655[urogenital system development] GO:0001656[metanephros development] GO:0001823[mesonephros development] GO:0002062[chondrocyte differentiation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008284[positive regulation of cell population proliferation] GO:0009792[embryo development ending in birth or egg hatching] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030501[positive regulation of bone mineralization] GO:0033687[osteoblast proliferation] GO:0035115[embryonic forelimb morphogenesis] GO:0035116[embryonic hindlimb morphogenesis] GO:0036023[embryonic skeletal limb joint morphogenesis] GO:0042474[middle ear morphogenesis] GO:0042476[odontogenesis] GO:0042733[embryonic digit morphogenesis] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048704[embryonic skeletal system morphogenesis] GO:0050679[positive regulation of epithelial cell proliferation] GO:0060021[roof of mouth development] GO:0060272[embryonic skeletal joint morphogenesis] GO:0060322[head development] GO:0060349[bone morphogenesis] GO:0061029[eyelid development in camera-type eye] GO:0072498[embryonic skeletal joint development] GO:1990837[sequence-specific double-stranded DNA binding]
Q8N2R0 [Direct mapping] Protein odd-skipped-related 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001655[urogenital system development] GO:0001656[metanephros development] GO:0001823[mesonephros development] GO:0002062[chondrocyte differentiation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008284[positive regulation of cell population proliferation] GO:0009792[embryo development ending in birth or egg hatching] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030501[positive regulation of bone mineralization] GO:0033687[osteoblast proliferation] GO:0035115[embryonic forelimb morphogenesis] GO:0035116[embryonic hindlimb morphogenesis] GO:0036023[embryonic skeletal limb joint morphogenesis] GO:0042474[middle ear morphogenesis] GO:0042476[odontogenesis] GO:0042733[embryonic digit morphogenesis] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048704[embryonic skeletal system morphogenesis] GO:0050679[positive regulation of epithelial cell proliferation] GO:0060021[roof of mouth development] GO:0060272[embryonic skeletal joint morphogenesis] GO:0060322[head development] GO:0060349[bone morphogenesis] GO:0061029[eyelid development in camera-type eye] GO:0072498[embryonic skeletal joint development] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
