We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q21.1
Chromosome location (bp)
52765380 - 52772784
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium-dependent lectin involved in innate immune defense 1. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response 2....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Lectin, Mannose-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001867[complement activation, lectin pathway] GO:0002376[immune system process] GO:0002682[regulation of immune system process] GO:0002752[cell surface pattern recognition receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005537[mannose binding] GO:0005576[extracellular region] GO:0005581[collagen trimer] GO:0005615[extracellular space] GO:0006508[proteolysis] GO:0006953[acute-phase response] GO:0006958[complement activation, classical pathway] GO:0006979[response to oxidative stress] GO:0008228[opsonization] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0030246[carbohydrate binding] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0045087[innate immune response] GO:0048306[calcium-dependent protein binding] GO:0048525[negative regulation of viral process] GO:0050830[defense response to Gram-positive bacterium] GO:0062023[collagen-containing extracellular matrix] GO:0140374[antiviral innate immune response] GO:1903028[positive regulation of opsonization] GO:1905370[serine-type endopeptidase complex]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001867[complement activation, lectin pathway] GO:0002376[immune system process] GO:0002682[regulation of immune system process] GO:0002752[cell surface pattern recognition receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005537[mannose binding] GO:0005576[extracellular region] GO:0005581[collagen trimer] GO:0005615[extracellular space] GO:0006508[proteolysis] GO:0006953[acute-phase response] GO:0006958[complement activation, classical pathway] GO:0006979[response to oxidative stress] GO:0008228[opsonization] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0030246[carbohydrate binding] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0045087[innate immune response] GO:0048306[calcium-dependent protein binding] GO:0048525[negative regulation of viral process] GO:0050766[positive regulation of phagocytosis] GO:0050830[defense response to Gram-positive bacterium] GO:0051873[killing by host of symbiont cells] GO:0062023[collagen-containing extracellular matrix] GO:0140374[antiviral innate immune response] GO:1903028[positive regulation of opsonization] GO:1905370[serine-type endopeptidase complex]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001867[complement activation, lectin pathway] GO:0002376[immune system process] GO:0002682[regulation of immune system process] GO:0002752[cell surface pattern recognition receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005537[mannose binding] GO:0005576[extracellular region] GO:0005581[collagen trimer] GO:0005615[extracellular space] GO:0006508[proteolysis] GO:0006953[acute-phase response] GO:0006958[complement activation, classical pathway] GO:0006979[response to oxidative stress] GO:0008228[opsonization] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0030246[carbohydrate binding] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0045087[innate immune response] GO:0048306[calcium-dependent protein binding] GO:0048525[negative regulation of viral process] GO:0050830[defense response to Gram-positive bacterium] GO:0062023[collagen-containing extracellular matrix] GO:0140374[antiviral innate immune response] GO:1903028[positive regulation of opsonization] GO:1905370[serine-type endopeptidase complex]
The Human Protein Atlas project is funded
