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PRPF18
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(1 genes):

C5orf22

 
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Blood group antigen proteins
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                                  • SUMMARY

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                                  • PRPF18
                                  IMMUNE CELL CELL LINEAGES Show tissue menu
                                  B-CELLS DENDRITIC CELLS GRANULOCYTES MONOCYTES NK-CELLS PROGENITORS T-CELLS TOTAL PBMC
                                  Immune cell proteome
                                  GENERAL INFORMATIONi

                                  General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

                                  Gene namei

                                  Official gene symbol, which is typically a short form of the gene name, according to HGNC.

                                  PRPF18
                                  Gene descriptioni

                                  Full gene name according to HGNC.

                                  Pre-mRNA processing factor 18
                                  Predicted locationi

                                  All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

                                  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

                                  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

                                  The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

                                  Intracellular
                                  IMMUNE CELL SECTION SUMMARY
                                  Immune cell type expression clusteri

                                  The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                  Non-specific - ATP binding (mainly)
                                  Immune cell type specificityi

                                  The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

                                  Low immune cell specificity
                                  Tau specificity scorei

                                  Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.

                                  0.10
                                  Immune cell type distributioni

                                  The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.

                                  Detected in all
                                  Immune cell lineage specificityi

                                  The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells.

                                  Low lineage specificity
                                  Immune cell lineage distributioni

                                  The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                  Detected in all
                                  IMMUNE CELL TYPE EXPRESSION (RNA)i

                                  Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.

                                  HPA dataseti

                                  The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC).

                                  Lineage
                                  Expression
                                  Alphabetical
                                  Immune cell type specificity: Low immune cell specificity
                                  BasophilEosinophilNeutrophilClassical monocyteNon-classical monocyteIntermediate monocyteT-regGdT-cellMAIT T-cellMemory CD4 T-cellNaive CD4 T-cellMemory CD8 T-cellNaive CD8 T-cellMemory B-cellNaive B-cellPlasmacytoid DCMyeloid DCNK-cellTotal PBMC01020304050nTPMGranulocytesMonocytesT-cellsB-cellsDendritic cellsNK-cellsTotal PBMC
                                  Monaco dataseti

                                  The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al.

                                  Lineage
                                  Expression
                                  Alphabetical
                                  BasophilNeutrophilClassical monocyteNon-classical monocyteIntermediate monocyteT-regMAIT T-cellNaive CD4 T-cellVd2 gdTCRMemory CD4 T-cell Th1/Th17Memory CD4 T-cell Th17Memory CD4 T-cell Th2Non-Vd2 gdTCRMemory CD4 T-cell Th1Memory CD4 T-cell TFHTerminal effector memory CD4 T-cellNaive CD8 T-cellCentral memory CD8 T-cellEffector memory CD8 T-cellTerminal effector memory CD8 T-cellNaive B-cellNon-switched memory B-cellPlasmablastSwitched memory B-cellExhausted memory B-cellPlasmacytoid DCMyeloid DCNK-cellProgenitor cellTotal PBMC020406080100nTPMGranulocytesMonocytesT-cellsB-cellsDendritic cellsNK-cellsProgenitorsTotal PBMC
                                  Schmiedel dataseti

                                  Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset.

                                  Lineage
                                  Expression
                                  Alphabetical
                                  Classical monocyteNon-classical monocyteNaive CD4 T-cellMemory CD4 T-cell TFHMemory CD4 T-cell Th1Memory CD4 T-cell Th1/Th17Memory CD4 T-cell Th17Memory CD4 T-cell Th2Memory T-regNaive CD4 T-cell activatedNaive CD8 T-cell activatedNaive T-regNaive CD8 T-cellNaive B-cellNK-cell05101520253035TPMMonocytesT-cellsB-cellsNK-cells
                                  EXPRESSION CLUSTERING & CORRELATIONi

                                  The RNA data was used to cluster genes according to their expression across samples. The resulting clusters have been manually annotated to describe common features in terms of function and specificity. The annotation of the cluster is displayed together with a confidence score of the gene's assignment to the cluster. The confidence is calculated as the fraction of times the gene was assigned to this cluster in repeated calculations and is reported between 0 to 1, where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. A table shows the 15 most similar genes in terms of expression profile.

                                  PRPF18 is part of cluster 33 Non-specific - ATP binding with confidencei

                                  Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

                                  0.9
                                  757 genes in cluster
                                  Go to interactive expression cluster page
                                  15 nearest neighbours based on immune cell RNA expression
                                  Neighbouri

                                  Gene name according to HGNC.

                                  Descriptioni

                                  Gene description according to HGNC.

                                  Correlationi

                                  Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

                                  Clusteri

                                  ID of the expression cluster of the neighboring gene.

                                  AKAP8L A-kinase anchoring protein 8 like 0.9524 33
                                  TNFRSF9 TNF receptor superfamily member 9 0.9286 33
                                  PCNX1 Pecanex 1 0.9286 33
                                  PPP1R15B Protein phosphatase 1 regulatory subunit 15B 0.9048 28
                                  UBE4B Ubiquitination factor E4B 0.9048 33
                                  JAK3 Janus kinase 3 0.9048 33
                                  SF3B1 Splicing factor 3b subunit 1 0.9048 33
                                  PRR19 Proline rich 19 0.8810 43
                                  ETV7 ETS variant transcription factor 7 0.8810 33
                                  TUFT1 Tuftelin 1 0.8810 33
                                  KDM3A Lysine demethylase 3A 0.8810 33
                                  GMDS GDP-mannose 4,6-dehydratase 0.8810 33
                                  CRYBG1 Crystallin beta-gamma domain containing 1 0.8810 33
                                  DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 0.8810 43
                                  SEC61A2 SEC61 translocon subunit alpha 2 0.8810 33

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