We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.33
Chromosome location (bp)
103556545 - 103562657
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding 1. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000774[adenyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006457[protein folding] GO:0007030[Golgi organization] GO:0010977[negative regulation of neuron projection development] GO:0016020[membrane] GO:0016234[inclusion body] GO:0019901[protein kinase binding] GO:0030314[junctional membrane complex] GO:0031397[negative regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051087[chaperone binding] GO:0051438[regulation of ubiquitin-protein transferase activity] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0061084[negative regulation of protein refolding] GO:0070997[neuron death] GO:0090083[regulation of inclusion body assembly] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000774[adenyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006457[protein folding] GO:0007030[Golgi organization] GO:0010977[negative regulation of neuron projection development] GO:0016020[membrane] GO:0016234[inclusion body] GO:0019901[protein kinase binding] GO:0030314[junctional membrane complex] GO:0031397[negative regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051087[chaperone binding] GO:0051438[regulation of ubiquitin-protein transferase activity] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0061084[negative regulation of protein refolding] GO:0070997[neuron death] GO:0090083[regulation of inclusion body assembly] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000774[adenyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006457[protein folding] GO:0007030[Golgi organization] GO:0010977[negative regulation of neuron projection development] GO:0016020[membrane] GO:0016234[inclusion body] GO:0019901[protein kinase binding] GO:0030314[junctional membrane complex] GO:0031397[negative regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0050821[protein stabilization] GO:0051087[chaperone binding] GO:0051438[regulation of ubiquitin-protein transferase activity] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0061084[negative regulation of protein refolding] GO:0070997[neuron death] GO:0090083[regulation of inclusion body assembly] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
