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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q15
Chromosome location (bp)
69470349 - 69579793
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001702[gastrulation with mouth forming second] GO:0001759[organ induction] GO:0002088[lens development in camera-type eye] GO:0003281[ventricular septum development] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005104[fibroblast growth factor receptor binding] GO:0005168[neurotrophin TRKA receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007185[transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007405[neuroblast proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0008595[anterior/posterior axis specification, embryo] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0019211[phosphatase activator activity] GO:0030900[forebrain development] GO:0042981[regulation of apoptotic process] GO:0043410[positive regulation of MAPK cascade] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0046619[lens placode formation involved in camera-type eye formation] GO:0050678[regulation of epithelial cell proliferation] GO:0060527[prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis] GO:0070307[lens fiber cell development] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:2000726[negative regulation of cardiac muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
