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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets Plasma proteins RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
Chromosome location (bp)
23835983 - 24220611
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity 1. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A 2. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 3. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P05771 [Direct mapping] Protein kinase C beta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0003682[chromatin binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006325[chromatin organization] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007077[mitotic nuclear membrane disassembly] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0010827[regulation of glucose transmembrane transport] GO:0010829[negative regulation of glucose transmembrane transport] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030374[nuclear receptor coactivator activity] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0035403[histone kinase activity (H3-T6 specific)] GO:0035556[intracellular signal transduction] GO:0042113[B cell activation] GO:0042393[histone binding] GO:0042953[lipoprotein transport] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687[post-translational protein modification] GO:0045766[positive regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0050853[B cell receptor signaling pathway] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070062[extracellular exosome] GO:0106310[protein serine kinase activity]
P05771 [Direct mapping] Protein kinase C beta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0003682[chromatin binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005080[protein kinase C binding] GO:0005246[calcium channel regulator activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006325[chromatin organization] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0006816[calcium ion transport] GO:0006874[cellular calcium ion homeostasis] GO:0006915[apoptotic process] GO:0007077[mitotic nuclear membrane disassembly] GO:0007165[signal transduction] GO:0007207[phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway] GO:0008091[spectrin] GO:0008270[zinc ion binding] GO:0010827[regulation of glucose transmembrane transport] GO:0010829[negative regulation of glucose transmembrane transport] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030374[nuclear receptor coactivator activity] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032024[positive regulation of insulin secretion] GO:0035403[histone kinase activity (H3-T6 specific)] GO:0035556[intracellular signal transduction] GO:0042113[B cell activation] GO:0042393[histone binding] GO:0042953[lipoprotein transport] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687[post-translational protein modification] GO:0044305[calyx of Held] GO:0045766[positive regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0050853[B cell receptor signaling pathway] GO:0050861[positive regulation of B cell receptor signaling pathway] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070062[extracellular exosome] GO:0071322[cellular response to carbohydrate stimulus] GO:0099171[presynaptic modulation of chemical synaptic transmission] GO:0099523[presynaptic cytosol] GO:0106310[protein serine kinase activity] GO:2000300[regulation of synaptic vesicle exocytosis]
The Human Protein Atlas project is funded
