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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q13.3
Chromosome location (bp)
32718004 - 32745106
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) 1. Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000902[cell morphogenesis] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0002092[positive regulation of receptor internalization] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0007165[signal transduction] GO:0008284[positive regulation of cell population proliferation] GO:0009887[animal organ morphogenesis] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0016015[] GO:0030199[collagen fibril organization] GO:0030297[transmembrane receptor protein tyrosine kinase activator activity] GO:0030502[negative regulation of bone mineralization] GO:0030514[negative regulation of BMP signaling pathway] GO:0032331[negative regulation of chondrocyte differentiation] GO:0033689[negative regulation of osteoblast proliferation] GO:0036122[BMP binding] GO:0038098[sequestering of BMP from receptor via BMP binding] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043184[vascular endothelial growth factor receptor 2 binding] GO:0045668[negative regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046851[negative regulation of bone remodeling] GO:0048018[receptor ligand activity] GO:0048263[determination of dorsal identity] GO:0051973[positive regulation of telomerase activity] GO:0055007[cardiac muscle cell differentiation] GO:0060173[limb development] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0062023[collagen-containing extracellular matrix] GO:0090027[negative regulation of monocyte chemotaxis] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090291[negative regulation of osteoclast proliferation] GO:1900086[positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900155[] GO:1900158[negative regulation of bone mineralization involved in bone maturation] GO:2000273[positive regulation of signaling receptor activity]
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902[cell morphogenesis] GO:0001525[angiogenesis] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0002092[positive regulation of receptor internalization] GO:0002689[negative regulation of leukocyte chemotaxis] GO:0003337[mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008284[positive regulation of cell population proliferation] GO:0009887[animal organ morphogenesis] GO:0009954[proximal/distal pattern formation] GO:0009986[cell surface] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0016015[] GO:0030199[collagen fibril organization] GO:0030297[transmembrane receptor protein tyrosine kinase activator activity] GO:0030308[negative regulation of cell growth] GO:0030326[embryonic limb morphogenesis] GO:0030502[negative regulation of bone mineralization] GO:0030514[negative regulation of BMP signaling pathway] GO:0032331[negative regulation of chondrocyte differentiation] GO:0033689[negative regulation of osteoblast proliferation] GO:0036122[BMP binding] GO:0038098[sequestering of BMP from receptor via BMP binding] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043184[vascular endothelial growth factor receptor 2 binding] GO:0043542[endothelial cell migration] GO:0045668[negative regulation of osteoblast differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046851[negative regulation of bone remodeling] GO:0048018[receptor ligand activity] GO:0048263[determination of dorsal identity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051893[regulation of focal adhesion assembly] GO:0051973[positive regulation of telomerase activity] GO:0055007[cardiac muscle cell differentiation] GO:0060173[limb development] GO:0060379[cardiac muscle cell myoblast differentiation] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0060676[ureteric bud formation] GO:0061098[positive regulation of protein tyrosine kinase activity] GO:0062023[collagen-containing extracellular matrix] GO:0090027[negative regulation of monocyte chemotaxis] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090190[positive regulation of branching involved in ureteric bud morphogenesis] GO:0090291[negative regulation of osteoclast proliferation] GO:1900086[positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900155[] GO:1900158[negative regulation of bone mineralization involved in bone maturation] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2000273[positive regulation of signaling receptor activity]
The Human Protein Atlas project is funded
