GENERAL INFORMATIONi
Gene namei PHB1
Synonyms PHB
Gene descriptioni Prohibitin 1
Protein classi Plasma proteins
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 17
Cytoband q21.33
Chromosome location (bp) 49404049 - 49414905
Number of transcriptsi 8
Ensembl ENSG00000167085 (version 109)
Entrez gene 5245
HGNC HGNC:8912
UniProt P35232 (UniProt - Evidence at protein level)
neXtProt NX_P35232
GeneCards PHB1
Antibodypedia PHB1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus 1, 2, 3, 4. Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). show less
Biological process (UniProt)i DNA synthesis, Host-virus interaction
Gene summary (Entrez)i This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PHB1-201
ENSP00000300408
ENST00000300408
P35232
[Direct mapping] Prohibitin 1
Show all
A8K401
[Target identity:100%; Query identity:100%] Prohibitin
Show all
Transporters
   Accessory Factors Involved in Transport
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001649 [osteoblast differentiation]
GO:0001850 [complement component C3a binding]
GO:0001851 [complement component C3b binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0023035 [CD40 signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0031871 [proteinase activated receptor binding]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0035632 [mitochondrial prohibitin complex]
GO:0039529 [RIG-I signaling pathway]
GO:0042113 [B cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044830 [modulation by host of viral RNA genome replication]
GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045917 [positive regulation of complement activation]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050821 [protein stabilization]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:0072538 [T-helper 17 type immune response]
GO:0140374 [antiviral innate immune response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1990051 [activation of protein kinase C activity]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 272 aa
29.8 kDa 		Yes 0
PHB1-203
ENSP00000393320
ENST00000419140
P35232
[Direct mapping] Prohibitin 1
Show all
C9JW96
[Direct mapping] Prohibitin
A8K401
[Target identity:100%; Query identity:100%] Prohibitin
Show all
Transporters
   Accessory Factors Involved in Transport
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001649 [osteoblast differentiation]
GO:0001850 [complement component C3a binding]
GO:0001851 [complement component C3b binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0023035 [CD40 signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0031871 [proteinase activated receptor binding]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0035632 [mitochondrial prohibitin complex]
GO:0039529 [RIG-I signaling pathway]
GO:0042113 [B cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044830 [modulation by host of viral RNA genome replication]
GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045917 [positive regulation of complement activation]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050821 [protein stabilization]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:0072538 [T-helper 17 type immune response]
GO:0140374 [antiviral innate immune response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1990051 [activation of protein kinase C activity]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 272 aa
29.8 kDa 		Yes 0
PHB1-205
ENSP00000407828
ENST00000446735
C9JZ20
[Direct mapping] Prohibitin
Show all
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
Show all
 218 aa
23.7 kDa 		Yes 0
PHB1-206
ENSP00000426433
ENST00000504124
P35232
[Direct mapping] Prohibitin 1
Show all
E9PCW0
[Direct mapping] Prohibitin
A8K401
[Target identity:100%; Query identity:100%] Prohibitin
Show all
Transporters
   Accessory Factors Involved in Transport
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001649 [osteoblast differentiation]
GO:0001850 [complement component C3a binding]
GO:0001851 [complement component C3b binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0023035 [CD40 signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0031871 [proteinase activated receptor binding]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0035632 [mitochondrial prohibitin complex]
GO:0039529 [RIG-I signaling pathway]
GO:0042113 [B cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044830 [modulation by host of viral RNA genome replication]
GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045917 [positive regulation of complement activation]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050821 [protein stabilization]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:0072538 [T-helper 17 type immune response]
GO:0140374 [antiviral innate immune response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1990051 [activation of protein kinase C activity]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 272 aa
29.8 kDa 		Yes 0
PHB1-210
ENSP00000425035
ENST00000511832
P35232
[Direct mapping] Prohibitin 1
Show all
A8K401
[Target identity:100%; Query identity:100%] Prohibitin
Show all
Transporters
   Accessory Factors Involved in Transport
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001649 [osteoblast differentiation]
GO:0001850 [complement component C3a binding]
GO:0001851 [complement component C3b binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0023035 [CD40 signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0031871 [proteinase activated receptor binding]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0035632 [mitochondrial prohibitin complex]
GO:0039529 [RIG-I signaling pathway]
GO:0042113 [B cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044830 [modulation by host of viral RNA genome replication]
GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045917 [positive regulation of complement activation]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050821 [protein stabilization]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:0072538 [T-helper 17 type immune response]
GO:0140374 [antiviral innate immune response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1990051 [activation of protein kinase C activity]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 272 aa
29.8 kDa 		Yes 0
PHB1-214
ENSP00000479488
ENST00000614445
P35232
[Direct mapping] Prohibitin 1
Show all
A8K401
[Target identity:100%; Query identity:100%] Prohibitin
Show all
Transporters
   Accessory Factors Involved in Transport
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001649 [osteoblast differentiation]
GO:0001850 [complement component C3a binding]
GO:0001851 [complement component C3b binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0023035 [CD40 signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0031871 [proteinase activated receptor binding]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0035632 [mitochondrial prohibitin complex]
GO:0039529 [RIG-I signaling pathway]
GO:0042113 [B cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044830 [modulation by host of viral RNA genome replication]
GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045917 [positive regulation of complement activation]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050821 [protein stabilization]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:0072538 [T-helper 17 type immune response]
GO:0140374 [antiviral innate immune response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1990051 [activation of protein kinase C activity]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 272 aa
29.8 kDa 		Yes 0
PHB1-215
ENSP00000484113
ENST00000617874
P35232
[Direct mapping] Prohibitin 1
Show all
A8K401
[Target identity:100%; Query identity:100%] Prohibitin
Show all
Transporters
   Accessory Factors Involved in Transport
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001649 [osteoblast differentiation]
GO:0001850 [complement component C3a binding]
GO:0001851 [complement component C3b binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0023035 [CD40 signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0031871 [proteinase activated receptor binding]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0035632 [mitochondrial prohibitin complex]
GO:0039529 [RIG-I signaling pathway]
GO:0042113 [B cell activation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044830 [modulation by host of viral RNA genome replication]
GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045917 [positive regulation of complement activation]
GO:0046718 [viral entry into host cell]
GO:0046982 [protein heterodimerization activity]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050821 [protein stabilization]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:0072538 [T-helper 17 type immune response]
GO:0140374 [antiviral innate immune response]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1990051 [activation of protein kinase C activity]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 272 aa
29.8 kDa 		Yes 0
PHB1-216
ENSP00000512581
ENST00000696365
   MEMSAT3 predicted membrane proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
 155 aa
17 kDa 		Yes 0

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