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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q12
Chromosome location (bp)
39461486 - 39564907
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0002944[cyclin K-CDK12 complex] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004693[cyclin-dependent protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006366[transcription by RNA polymerase II] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0006397[mRNA processing] GO:0006468[protein phosphorylation] GO:0008024[cyclin/CDK positive transcription elongation factor complex] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0008380[RNA splicing] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0019908[nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0030332[cyclin binding] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0043405[regulation of MAP kinase activity] GO:0046777[protein autophosphorylation] GO:0051726[regulation of cell cycle] GO:0070816[phosphorylation of RNA polymerase II C-terminal domain] GO:0106310[protein serine kinase activity]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0002944[cyclin K-CDK12 complex] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004693[cyclin-dependent protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006366[transcription by RNA polymerase II] GO:0006368[transcription elongation by RNA polymerase II promoter] GO:0006397[mRNA processing] GO:0006468[protein phosphorylation] GO:0008024[cyclin/CDK positive transcription elongation factor complex] GO:0008353[RNA polymerase II CTD heptapeptide repeat kinase activity] GO:0008380[RNA splicing] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0019908[nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0030332[cyclin binding] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0043405[regulation of MAP kinase activity] GO:0043484[regulation of RNA splicing] GO:0046777[protein autophosphorylation] GO:0051726[regulation of cell cycle] GO:0070816[phosphorylation of RNA polymerase II C-terminal domain] GO:0106310[protein serine kinase activity] GO:2000737[negative regulation of stem cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
