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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
Not detected
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
67.6
nTPM
HPA Brain:
150.6
nTPM
GTEx:
67.6
nTPM
FANTOM5:
120.3
Scaled Tags Per Million
Pig:
160.8
nTPM
Mouse:
144.6
nTPM
HIPPOCAMPUS - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA014447
Antibody HPA048045
Glial cells
Not detected
Not detected
Neuronal cells
Not detected
Not detected
HIPPOCAMPAL FORMATION - HPA Brain RNA-seq
Max nTPM
150.6
Sample id
Sample description
nTPM
Hippocampus nTPM: 106.1
2621
Female, age 67, right hemisphere
117.5
1855
Male, age 76, left hemisphere
113.9
2148
Female, age 91, left hemisphere
109.4
1898
Male, age 80, left hemisphere
108.7
1911
Female, age 85, right hemisphere
108.2
2529
Female, age 94, left hemisphere
78.8
Dentate gyrus nTPM: 116.0
2530
Female, age 94, left hemisphere
148.0
2531
Female, age 67, both hemispheres
125.4
2246
Female, age 85, both hemispheres
116.6
2528
Male, age 74, both hemispheres
112.5
1927
Female, age 91, both hemispheres
101.0
2010
Male, age 76, both hemispheres
92.3
Entorhinal gyrus nTPM: 132.6
2613
Female, age 94, left hemisphere
198.6
2764
Male, age 80, right hemisphere
143.6
1938
Female, age 85, left hemisphere
135.0
1787
Male, age 76, left hemisphere
131.6
2686
Male, age 75, right hemisphere
122.9
2117
Female, age 91, right hemisphere
64.0
Hippocampus, CA1 nTPM: 105.3
2082
Female, age 91, right hemisphere
111.5
1873
Female, age 85, both hemispheres
110.9
2749
Male, age 80, left hemisphere
105.8
2527
Male, age 74, both hemispheres
103.9
2045
Male, age 76, both hemispheres
94.5
Hippocampus, CA2 nTPM: 108.6
2437
Female, age 94, left hemisphere
138.2
1892
Male, age 76, both hemispheres
115.0
2113
Female, age 91, right hemisphere
113.7
1940
Female, age 85, left hemisphere
109.0
2249
Male, age 74, both hemispheres
103.7
1963
Male, age 80, left hemisphere
72.2
Hippocampus, CA3 nTPM: 104.4
2620
Female, age 94, left hemisphere
152.3
2861
Female, age 67, both hemispheres
122.5
2137
Male, age 80, left hemisphere
116.0
2436
Male, age 74, both hemispheres
84.4
1891
Female, age 85, both hemispheres
77.6
1867
Male, age 76, both hemispheres
73.7
Parahippocampal cortex nTPM: 139.8
2532
Female, age 72, left hemisphere
171.4
2245
Female, age 91, both hemispheres
171.1
2622
Female, age 67, right hemisphere
170.2
2693
Female, age 94, both hemispheres
156.9
2250
Female, age 67, right hemisphere
148.1
1933
Female, age 85, both hemispheres
140.9
1850
Male, age 80, both hemispheres
133.5
2692
Male, age 74, both hemispheres
110.7
1990
Female, age 91, right hemisphere
107.2
2018
Male, age 76, both hemispheres
88.2
Perirhinal gyrus nTPM: 150.6
1847
Female, age 91, left hemisphere
168.9
1841
Female, age 85, right hemisphere
162.1
2848
Male, age 76, right hemisphere
145.7
1794
Male, age 80, right hemisphere
139.9
2521
Female, age 94, right hemisphere
136.2
Subiculum nTPM: 95.3
2438
Female, age 94, left hemisphere
110.0
2619
Male, age 74, both hemispheres
106.4
1901
Male, age 80, both hemispheres
94.2
1977
Female, age 85, both hemispheres
92.2
2729
Female, age 91, right hemisphere
88.3
2042
Male, age 76, both hemispheres
80.5
HIPPOCAMPAL FORMATION - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Average nTPM
67.6
GTEx sample id
Sample description
nTPM
Brain - Hippocampus Average nTPM: 67.6
Samples: 197
Max nTPM: 156.0
Min nTPM: 5.6
Std nTPM: 33.1
Median nTPM: 69.0
GTEX-145MH-0011-R1b-SM-5PNWY
50-59 years, male
156.0
GTEX-13FLW-0011-R1b-SM-5LZX2
50-59 years, male
153.5
GTEX-1EWIQ-0011-R1a-SM-9OSX7
70-79 years, female
150.8
GTEX-P44G-0011-R1A-SM-2I3FE
30-39 years, male
148.6
GTEX-13O3O-0011-R1b-SM-5KM2K
60-69 years, female
148.4
GTEX-13O3Q-0011-R1b-SM-5KM3L
50-59 years, male
137.0
GTEX-WHSE-0011-R1A-SM-3P5ZK
20-29 years, male
132.4
GTEX-14C5O-0011-R1b-SM-6AJBW
60-69 years, male
129.5
GTEX-1GTWX-0011-R1a-SM-CE6RL
60-69 years, male
126.1
GTEX-12WSD-0011-R1b-SM-5LZVY
60-69 years, female
126.0
GTEX-TSE9-0011-R1A-SM-3DB7E
60-69 years, female
125.3
GTEX-1I1HK-0011-R1b-SM-CM2T7
60-69 years, male
122.6
GTEX-NL3H-0011-R1a-SM-48TDJ
60-69 years, male
120.6
GTEX-WL46-0011-R1A-SM-3LK6M
50-59 years, male
119.6
GTEX-R55E-0011-R1A-SM-2TC6N
20-29 years, male
118.6
GTEX-139TT-0011-R1a-SM-5LZVD
60-69 years, male
117.8
GTEX-1F75A-0011-R1b-SM-CE6RA
50-59 years, male
117.7
GTEX-1ICLZ-0011-R1b-SM-A9SM3
60-69 years, male
114.6
GTEX-14BIM-0011-R1a-SM-69LQI
60-69 years, female
113.6
GTEX-1EX96-0011-R1a-SM-CE6R5
50-59 years, male
113.3
GTEX-144GL-0011-R1a-SM-5PNZ5
50-59 years, male
113.2
GTEX-1HT8W-0011-R1b-SM-CJI3V
30-39 years, male
113.0
GTEX-13OW7-0011-R1b-SM-5L3HF
50-59 years, male
112.7
GTEX-131XH-0011-R1a-SM-5DUWA
50-59 years, male
111.9
GTEX-Y8DK-0011-R1A-SM-4RGLO
60-69 years, male
110.9
GTEX-WWYW-0011-R1A-SM-3TW8G
50-59 years, female
109.9
GTEX-1H1ZS-0011-R1b-SM-A9G1E
70-79 years, male
108.1
GTEX-S7SE-0011-R1A-SM-2XCDE
50-59 years, male
106.1
GTEX-RNOR-0011-R1A-SM-CNNP5
50-59 years, female
105.3
GTEX-1GZ2Q-0011-R1a-SM-CJI2Y
40-49 years, male
104.0
GTEX-11ONC-0011-R1a-SM-57WD4
60-69 years, male
102.6
GTEX-12WSE-0011-R1b-SM-5GU4V
20-29 years, male
102.4
GTEX-13JUV-0011-R1a-SM-5LZY4
40-49 years, female
99.3
GTEX-13FXS-0011-R1a-SM-5K7U6
50-59 years, male
97.1
GTEX-1H3NZ-0011-R1a-SM-CKZP5
60-69 years, male
95.9
GTEX-1HSMO-0011-R1a-SM-CM2SV
60-69 years, male
95.2
GTEX-QDT8-0011-R1A-SM-32PKS
30-39 years, female
94.3
GTEX-139T8-0011-R1a-SM-5HL75
60-69 years, male
94.2
GTEX-X585-0011-R1B-SM-46MVE
50-59 years, male
93.3
GTEX-13112-0011-R1b-SM-5HL7K
50-59 years, male
93.2
GTEX-YFC4-0011-R1a-SM-4V6EH
40-49 years, female
92.1
GTEX-1F48J-0011-R1a-SM-9QEIC
50-59 years, female
92.1
GTEX-1I1GS-0011-R1a-SM-CJI43
60-69 years, male
91.5
GTEX-1J1OQ-0011-R1a-SM-A9G1Z
40-49 years, female
91.4
GTEX-14JIY-0011-R1a-SM-68713
60-69 years, male
91.2
GTEX-13G51-0011-R1a-SM-5LZYR
60-69 years, male
90.3
GTEX-16Z82-0011-R1b-SM-7EPHZ
60-69 years, male
89.4
GTEX-N7MS-0011-R1a-SM-2HMJG
60-69 years, male
88.9
GTEX-T5JC-0011-R1A-SM-32PM6
20-29 years, male
88.5
GTEX-14E6D-0011-R1b-SM-5YYAW
50-59 years, male
87.8
GTEX-1IY9M-0011-R1a-SM-EXURZ
60-69 years, male
87.7
GTEX-1CB4G-0011-R1b-SM-9QEHT
60-69 years, male
87.3
GTEX-13NYB-0011-R1b-SM-5KM4F
40-49 years, male
87.2
GTEX-12WSM-0011-R1a-SM-5LZW6
60-69 years, male
87.1
GTEX-NPJ7-0011-R1a-SM-3GACT
60-69 years, female
87.0
GTEX-ZDXO-0011-R1a-SM-4WKF4
60-69 years, male
86.9
GTEX-11GSP-0011-R1a-SM-9QEJ3
60-69 years, female
85.5
GTEX-13X6I-0011-R1b-SM-5PNZC
60-69 years, male
84.9
GTEX-17F97-0011-R1b-SM-7IGM9
50-59 years, male
84.4
GTEX-1A8G6-0011-R1a-SM-7P8PC
60-69 years, male
83.5
GTEX-WVLH-0011-R1A-SM-4MVOK
50-59 years, male
83.4
GTEX-13FHO-0011-R1b-SM-5KLZG
60-69 years, male
83.2
GTEX-1GMR8-0011-R1b-SM-CJI2O
50-59 years, female
82.6
GTEX-1EMGI-0011-R1b-SM-9OSWZ
60-69 years, male
82.5
GTEX-1GN1U-0011-R1a-SM-CJI25
50-59 years, female
82.4
GTEX-1AX9I-0011-R1b-SM-7RHG2
60-69 years, male
82.3
GTEX-14ASI-0011-R1b-SM-5S2TY
60-69 years, male
81.9
GTEX-1313W-0011-R1b-SM-5EQ4A
50-59 years, female
80.6
GTEX-1GF9W-0011-R1a-SM-9QEIQ
60-69 years, male
80.6
GTEX-11EI6-0011-R1a-SM-DO93L
60-69 years, male
80.2
GTEX-1E1VI-0011-R1a-SM-ARZMM
50-59 years, male
79.9
GTEX-1C6VR-0011-R1a-SM-7MXUE
60-69 years, male
79.8
GTEX-13FTY-0011-R1a-SM-5LZXE
40-49 years, female
79.2
GTEX-13SLW-0011-R1a-SM-5S2W7
70-79 years, male
79.1
GTEX-Q2AG-0011-R1A-SM-2HMJI
40-49 years, female
78.6
GTEX-QVJO-0011-R1A-SM-2S1QI
60-69 years, female
78.6
GTEX-14LLW-0011-R1a-SM-5ZZVD
70-79 years, female
78.4
GTEX-1B8SF-0011-R1b-SM-7P8Q8
60-69 years, male
77.9
GTEX-ZF28-0011-R1a-SM-4WWD1
60-69 years, male
77.8
GTEX-13OW6-0011-R1a-SM-5L3HQ
50-59 years, male
77.2
GTEX-1IOXB-0011-R1a-SM-D4P27
50-59 years, male
76.8
GTEX-ZAB4-0011-R1a-SM-4RGNO
40-49 years, male
76.4
GTEX-1IDJH-0011-R1b-SM-ARU6U
70-79 years, male
75.8
GTEX-P44H-0011-R1A-SM-3NM8J
40-49 years, male
75.4
GTEX-1A3MX-0011-R1b-SM-7P8PH
60-69 years, male
73.6
GTEX-15DCD-0011-R1b-SM-6LPIJ
70-79 years, female
72.9
GTEX-X4XX-0011-R1B-SM-3P622
60-69 years, male
72.4
GTEX-14ABY-0011-R1a-SM-6EU2W
50-59 years, male
72.2
GTEX-13PDP-0011-R1a-SM-5PNX5
60-69 years, male
72.1
GTEX-14PN4-0011-R1b-SM-69LP8
50-59 years, male
72.0
GTEX-13CF2-0011-R1a-SM-5LZY1
60-69 years, male
71.7
GTEX-12WSH-0011-R1a-SM-5GU5V
50-59 years, male
70.9
GTEX-1IKK5-0011-R1b-SM-CE6SQ
60-69 years, male
70.5
GTEX-1H3VE-0011-R1a-SM-A9G1K
40-49 years, male
70.0
GTEX-17HG3-0011-R1a-SM-7LG6H
30-39 years, female
69.8
GTEX-13N2G-0011-R1b-SM-5MR3G
60-69 years, male
69.5
GTEX-16XZZ-0011-R1a-SM-7LTAH
60-69 years, male
69.3
GTEX-11GS4-0011-R1a-SM-DO129
60-69 years, male
69.3
GTEX-1GN2E-0011-R1b-SM-CE6RJ
60-69 years, male
69.0
GTEX-1F6I4-0011-R1a-SM-9OSWU
60-69 years, male
68.7
GTEX-YJ89-0011-R1a-SM-4RGLS
60-69 years, male
67.4
GTEX-PVOW-0011-R1A-SM-32PL6
40-49 years, male
67.0
GTEX-11DXW-0011-R1a-SM-DNZZD
40-49 years, male
66.8
GTEX-17HHY-0011-R1a-SM-7189V
50-59 years, male
65.0
GTEX-12WSF-0011-R1a-SM-5DUVI
70-79 years, male
64.8
GTEX-ZE7O-0011-R1a-SM-57WDM
50-59 years, female
64.3
GTEX-13N1W-0011-R1b-SM-5MR4T
70-79 years, male
64.2
GTEX-16YQH-0011-R1a-SM-7LT8R
30-39 years, male
62.8
GTEX-OHPN-0011-R1A-SM-2I5GB
60-69 years, female
62.0
GTEX-1EH9U-0011-R1b-SM-CJI2B
60-69 years, male
59.1
GTEX-15ER7-0011-R1b-SM-7KUE1
20-29 years, female
58.0
GTEX-13RTL-0011-R1a-SM-5PNZ8
40-49 years, male
57.0
GTEX-1HSKV-0011-R1b-SM-CMKH7
60-69 years, male
56.4
GTEX-QMR6-0011-R1A-SM-32PKW
50-59 years, male
56.3
GTEX-1B933-0011-R1b-SM-9QEGW
50-59 years, female
56.1
GTEX-11WQC-0011-R1b-SM-DO932
60-69 years, male
55.0
GTEX-ZVZQ-0011-R1a-SM-57WBU
60-69 years, female
54.4
GTEX-1B8L1-0011-R1a-SM-7P8SS
60-69 years, male
54.2
GTEX-T6MN-0011-R1A-SM-32QOY
50-59 years, male
53.4
GTEX-12ZZX-0011-R1a-SM-5EQ6B
40-49 years, female
53.3
GTEX-PWO3-0011-R1A-SM-2I5EW
60-69 years, female
53.3
GTEX-QVUS-0011-R1A-SM-3GAD2
60-69 years, female
53.0
GTEX-1EKGG-0011-R1b-SM-9QEI1
60-69 years, male
52.3
GTEX-13FHP-0011-R1b-SM-5K7XL
50-59 years, male
52.1
GTEX-1C64N-0011-R1b-SM-7P8Q7
50-59 years, male
51.5
GTEX-13S7M-0011-R1b-SM-5PNZE
60-69 years, female
51.3
GTEX-17EVP-0011-R1a-SM-7DHLA
40-49 years, male
50.8
GTEX-1LG7Y-0011-R1a-SM-EYYWV
50-59 years, male
49.3
GTEX-N7MT-0011-R1a-SM-CNPO1
60-69 years, female
49.0
GTEX-1H3O1-0011-R1b-SM-CL554
60-69 years, male
48.8
GTEX-14PJM-0011-R1a-SM-CNPO3
50-59 years, female
48.7
GTEX-132Q8-0011-R1a-SM-5EGLK
60-69 years, male
48.3
GTEX-145LU-0011-R1a-SM-5Q5CE
50-59 years, male
47.3
GTEX-1399T-0011-R1b-SM-5DUWN
60-69 years, male
47.2
GTEX-1I1GQ-0011-R1a-SM-CY8GG
50-59 years, male
47.1
GTEX-1GN73-0011-R1a-SM-CKZNT
60-69 years, male
46.0
GTEX-1F6IF-0011-R1b-SM-9WG78
60-69 years, male
45.4
GTEX-1HBPI-0011-R1b-SM-A9SKF
50-59 years, male
45.4
GTEX-17JCI-0011-R1b-SM-718A3
60-69 years, female
44.7
GTEX-14PJO-0011-R1b-SM-6AJAK
60-69 years, male
42.7
GTEX-17HII-0011-R1b-SM-7MGVW
50-59 years, male
42.6
GTEX-1J8Q2-0011-R1a-SM-D4P2D
60-69 years, male
42.4
GTEX-13OVJ-0011-R1b-SM-5L3I6
50-59 years, female
42.3
GTEX-1GF9V-0011-R1a-SM-CKZNQ
60-69 years, male
42.3
GTEX-WZTO-0011-R1B-SM-3NMAR
40-49 years, male
42.1
GTEX-1F75W-0011-R1a-SM-ARU81
60-69 years, male
41.0
GTEX-11GSO-0011-R1b-SM-57WD3
60-69 years, male
40.8
GTEX-1C6VQ-0011-R1a-SM-7P8Q2
50-59 years, male
39.9
GTEX-1HR98-0011-R1a-SM-ARZLQ
60-69 years, male
39.5
GTEX-144GO-0011-R1a-SM-5PNWO
60-69 years, male
39.1
GTEX-14E7W-0011-R1b-SM-5YYAT
70-79 years, male
39.0
GTEX-11UD1-0011-R1b-SM-5BC7D
40-49 years, female
38.7
GTEX-ZUA1-0011-R1a-SM-4YCE2
40-49 years, male
38.5
GTEX-13OW5-0011-R1b-SM-5L3GE
60-69 years, male
38.2
GTEX-1GZHY-0011-R1a-SM-CE6RR
50-59 years, female
37.7
GTEX-13RTJ-0011-R1a-SM-5O9D9
60-69 years, male
36.9
GTEX-1E2YA-0011-R1b-SM-CJI29
50-59 years, male
35.5
GTEX-15CHQ-0011-R1a-SM-COH27
60-69 years, male
35.3
GTEX-13OVL-0011-R1a-SM-5L3H5
50-59 years, male
34.9
GTEX-145LS-0011-R1b-SM-5PNUP
60-69 years, female
34.6
GTEX-17EVQ-0011-R1a-SM-7189S
70-79 years, male
34.0
GTEX-17MF6-0011-R1a-SM-72D6O
40-49 years, male
33.9
GTEX-14PQA-0011-R1b-SM-6EU1G
50-59 years, female
33.8
GTEX-NPJ8-0011-R1a-SM-33HCB
40-49 years, male
32.4
GTEX-1H1DG-0011-R1b-SM-CKZP1
70-79 years, male
32.0
GTEX-1212Z-0011-R1b-SM-5BC72
60-69 years, male
31.6
GTEX-1B996-0011-R1b-SM-7P8PO
60-69 years, male
31.4
GTEX-1HGF4-0011-R1a-SM-CJI3S
60-69 years, male
31.4
GTEX-15UF6-0011-R1a-SM-9QEGH
70-79 years, female
31.0
GTEX-13OW8-0011-R1a-SM-5L3HI
60-69 years, male
30.9
GTEX-14LZ3-0011-R1a-SM-69LP5
60-69 years, female
30.7
GTEX-1LB8K-0011-R1b-SM-EZ6MV
50-59 years, male
30.6
GTEX-1H1CY-0011-R1a-SM-CKZOZ
60-69 years, female
30.5
GTEX-X4EP-0011-R1A-SM-3P624
60-69 years, female
30.2
GTEX-16NPV-0011-R1b-SM-7MGVZ
50-59 years, female
30.2
GTEX-131YS-0011-R1a-SM-5DUXC
60-69 years, female
29.8
GTEX-183WM-0011-R1a-SM-718A8
70-79 years, female
27.9
GTEX-13QJC-0011-R1b-SM-5S2UU
60-69 years, female
27.5
GTEX-13NYS-0011-R1b-SM-5MR55
60-69 years, male
25.4
GTEX-16GPK-0011-R1b-SM-7EWDH
60-69 years, male
25.0
GTEX-13NZ8-0011-R1b-SM-5KM3V
60-69 years, female
24.3
GTEX-1I1GV-0011-R1a-SM-CL559
60-69 years, male
24.1
GTEX-UTHO-0011-R1A-SM-3GIJO
60-69 years, male
23.7
GTEX-XMD1-0011-R1A-SM-4AT4C
60-69 years, male
21.5
GTEX-13JVG-0011-R1a-SM-5KM32
60-69 years, male
21.3
GTEX-1CAV2-0011-R1a-SM-ARZML
40-49 years, female
20.9
GTEX-1A32A-0011-R1a-SM-7P8SQ
50-59 years, female
20.5
GTEX-1BAJH-0011-R1a-SM-7P8SV
70-79 years, male
19.5
GTEX-11ZVC-0011-R1b-SM-5BC6M
50-59 years, female
19.1
GTEX-13QIC-0011-R1a-SM-5O9CJ
60-69 years, female
17.7
GTEX-13NZA-0011-R1b-SM-5LUAF
60-69 years, male
16.2
GTEX-1H4P4-0011-R1b-SM-CL54V
50-59 years, male
13.2
GTEX-1H23P-0011-R1a-SM-ACKVC
60-69 years, male
12.6
GTEX-18A6Q-0011-R1b-SM-731DI
60-69 years, male
10.4
GTEX-11ZTS-0011-R1a-SM-5BC71
60-69 years, female
9.1
GTEX-11TUW-0011-R1a-SM-DO92S
60-69 years, male
7.0
GTEX-1CB4J-0011-R1a-SM-9WG64
60-69 years, male
5.6
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HIPPOCAMPAL FORMATION - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.