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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
p13.3
Chromosome location (bp)
2204248 - 2209453
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9BVC4 [Direct mapping] Target of rapamycin complex subunit LST8
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006974[cellular response to DNA damage stimulus] GO:0007010[cytoskeleton organization] GO:0010507[negative regulation of autophagy] GO:0016310[phosphorylation] GO:0030307[positive regulation of cell growth] GO:0031669[cellular response to nutrient levels] GO:0031929[TOR signaling] GO:0031931[TORC1 complex] GO:0031932[TORC2 complex] GO:0032008[positive regulation of TOR signaling] GO:0032956[regulation of actin cytoskeleton organization] GO:0038202[TORC1 signaling] GO:0043066[negative regulation of apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045821[positive regulation of glycolytic process] GO:0046889[positive regulation of lipid biosynthetic process] GO:0071456[cellular response to hypoxia] GO:0071470[cellular response to osmotic stress] GO:1905857[positive regulation of pentose-phosphate shunt]
Q9BVC4 [Direct mapping] Target of rapamycin complex subunit LST8
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006974[cellular response to DNA damage stimulus] GO:0007010[cytoskeleton organization] GO:0010507[negative regulation of autophagy] GO:0016310[phosphorylation] GO:0030307[positive regulation of cell growth] GO:0031669[cellular response to nutrient levels] GO:0031929[TOR signaling] GO:0031931[TORC1 complex] GO:0031932[TORC2 complex] GO:0032008[positive regulation of TOR signaling] GO:0032956[regulation of actin cytoskeleton organization] GO:0038202[TORC1 signaling] GO:0043066[negative regulation of apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045821[positive regulation of glycolytic process] GO:0046889[positive regulation of lipid biosynthetic process] GO:0071456[cellular response to hypoxia] GO:0071470[cellular response to osmotic stress] GO:1905857[positive regulation of pentose-phosphate shunt]
Q9BVC4 [Direct mapping] Target of rapamycin complex subunit LST8
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006974[cellular response to DNA damage stimulus] GO:0007010[cytoskeleton organization] GO:0010507[negative regulation of autophagy] GO:0016310[phosphorylation] GO:0030307[positive regulation of cell growth] GO:0031669[cellular response to nutrient levels] GO:0031929[TOR signaling] GO:0031931[TORC1 complex] GO:0031932[TORC2 complex] GO:0032008[positive regulation of TOR signaling] GO:0032956[regulation of actin cytoskeleton organization] GO:0038202[TORC1 signaling] GO:0043066[negative regulation of apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045821[positive regulation of glycolytic process] GO:0046889[positive regulation of lipid biosynthetic process] GO:0071456[cellular response to hypoxia] GO:0071470[cellular response to osmotic stress] GO:1905857[positive regulation of pentose-phosphate shunt]
Q9BVC4 [Direct mapping] Target of rapamycin complex subunit LST8
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006974[cellular response to DNA damage stimulus] GO:0007010[cytoskeleton organization] GO:0010507[negative regulation of autophagy] GO:0016310[phosphorylation] GO:0030307[positive regulation of cell growth] GO:0031669[cellular response to nutrient levels] GO:0031929[TOR signaling] GO:0031931[TORC1 complex] GO:0031932[TORC2 complex] GO:0032008[positive regulation of TOR signaling] GO:0032956[regulation of actin cytoskeleton organization] GO:0038202[TORC1 signaling] GO:0043066[negative regulation of apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045821[positive regulation of glycolytic process] GO:0046889[positive regulation of lipid biosynthetic process] GO:0071456[cellular response to hypoxia] GO:0071470[cellular response to osmotic stress] GO:1905857[positive regulation of pentose-phosphate shunt]
Q9BVC4 [Direct mapping] Target of rapamycin complex subunit LST8
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006974[cellular response to DNA damage stimulus] GO:0007010[cytoskeleton organization] GO:0010507[negative regulation of autophagy] GO:0016310[phosphorylation] GO:0030307[positive regulation of cell growth] GO:0030838[positive regulation of actin filament polymerization] GO:0031669[cellular response to nutrient levels] GO:0031929[TOR signaling] GO:0031931[TORC1 complex] GO:0031932[TORC2 complex] GO:0032008[positive regulation of TOR signaling] GO:0032956[regulation of actin cytoskeleton organization] GO:0038202[TORC1 signaling] GO:0043066[negative regulation of apoptotic process] GO:0043087[regulation of GTPase activity] GO:0043539[protein serine/threonine kinase activator activity] GO:0045821[positive regulation of glycolytic process] GO:0046889[positive regulation of lipid biosynthetic process] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0071456[cellular response to hypoxia] GO:0071470[cellular response to osmotic stress] GO:1905857[positive regulation of pentose-phosphate shunt]
The Human Protein Atlas project is funded
