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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
p14
Chromosome location (bp)
40191011 - 40246967
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
GTP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q15669 [Direct mapping] Rho-related GTP-binding protein RhoH
Show all
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
D6RG23 [Direct mapping] Rho-related GTP-binding protein RhoH Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q15669 [Direct mapping] Rho-related GTP-binding protein RhoH
Show all
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
D6RA52 [Direct mapping] Rho-related GTP-binding protein RhoH Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
D6R8Z1 [Direct mapping] Rho-related GTP-binding protein RhoH Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q15669 [Direct mapping] Rho-related GTP-binding protein RhoH
Show all
Q6ICP4 [Target identity:100%; Query identity:100%] ARHH protein; Ras homolog gene family, member H, isoform CRA_a; cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
