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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Signal transducer and activator of transcription 3
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.2
Chromosome location (bp)
42313324 - 42388540
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors 1,2,3,4,5,6,7,8. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene 9. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 10. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes 11. Activated by IL31 through IL31RA 12. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity 13. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 14. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation 15. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity 16. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010467[gene expression] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035019[somatic stem cell population maintenance] GO:0035591[signaling adaptor activity] GO:0040014[regulation of multicellular organism growth] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0043565[sequence-specific DNA binding] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045820[negative regulation of glycolytic process] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060221[retinal rod cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0097398[cellular response to interleukin-17] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing] GO:2000737[negative regulation of stem cell differentiation] GO:2001223[negative regulation of neuron migration]
G8JLH9 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
A0A7I2YQI1 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
A0A7I2V2G1 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V3V0 [Direct mapping] Signal transducer and activator of transcription
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2YQR5 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V395 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V4R3 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
A0A7I2V444 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
A0A7I2V4C8 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V4R3 [Direct mapping] Signal transducer and activator of transcription
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V4R2 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V552 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V5N9 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
A0A7I2YQD2 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
A0A7I2V5N9 [Direct mapping] Signal transducer and activator of transcription
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001659[temperature homeostasis] GO:0001754[eye photoreceptor cell differentiation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006606[protein import into nucleus] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007399[nervous system development] GO:0010507[negative regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016310[phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0019953[sexual reproduction] GO:0030335[positive regulation of cell migration] GO:0030522[intracellular receptor signaling pathway] GO:0031490[chromatin DNA binding] GO:0032355[response to estradiol] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032870[cellular response to hormone stimulus] GO:0033210[leptin-mediated signaling pathway] GO:0035591[signaling adaptor activity] GO:0042127[regulation of cell population proliferation] GO:0042593[glucose homeostasis] GO:0042755[eating behavior] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0044320[cellular response to leptin stimulus] GO:0044321[response to leptin] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048708[astrocyte differentiation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051726[regulation of cell cycle] GO:0060019[radial glial cell differentiation] GO:0060259[regulation of feeding behavior] GO:0060396[growth hormone receptor signaling pathway] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070102[interleukin-6-mediated signaling pathway] GO:0070878[primary miRNA binding] GO:0072538[T-helper 17 type immune response] GO:0072540[T-helper 17 cell lineage commitment] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097009[energy homeostasis] GO:0140297[DNA-binding transcription factor binding] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1902895[positive regulation of miRNA transcription] GO:1904685[positive regulation of metalloendopeptidase activity] GO:2000635[negative regulation of primary miRNA processing] GO:2000637[positive regulation of miRNA-mediated gene silencing]
A0A7I2V4C8 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
A0A7I2V395 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Human disease related genes Cancers Head and neck cancers Immune system diseases Allergies and autoimmune diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0090575[RNA polymerase II transcription regulator complex]
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