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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q35.3
Chromosome location (bp)
177303799 - 177306949
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Lipid transport, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9Y255 [Direct mapping] PRELI domain-containing protein 1, mitochondrial
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0005758[mitochondrial intermembrane space] GO:0006869[lipid transport] GO:0006915[apoptotic process] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0010950[positive regulation of endopeptidase activity] GO:0015914[phospholipid transport] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0045580[regulation of T cell differentiation] GO:0051881[regulation of mitochondrial membrane potential] GO:0070234[positive regulation of T cell apoptotic process] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097035[regulation of membrane lipid distribution] GO:0120009[intermembrane lipid transfer] GO:1901857[positive regulation of cellular respiration] GO:1990050[phosphatidic acid transfer activity] GO:2001140[positive regulation of phospholipid transport]
Q9Y255 [Direct mapping] PRELI domain-containing protein 1, mitochondrial
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0005758[mitochondrial intermembrane space] GO:0006869[lipid transport] GO:0006915[apoptotic process] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0010950[positive regulation of endopeptidase activity] GO:0015914[phospholipid transport] GO:0032991[protein-containing complex] GO:0043066[negative regulation of apoptotic process] GO:0045580[regulation of T cell differentiation] GO:0051881[regulation of mitochondrial membrane potential] GO:0070234[positive regulation of T cell apoptotic process] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097035[regulation of membrane lipid distribution] GO:0120009[intermembrane lipid transfer] GO:1901857[positive regulation of cellular respiration] GO:1990050[phosphatidic acid transfer activity] GO:2001140[positive regulation of phospholipid transport]
The Human Protein Atlas project is funded
