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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Potassium voltage-gated channel subfamily A regulatory beta subunit 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q25.31
Chromosome location (bp)
156037701 - 156539138
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits 1,2,3,4,5. Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members 6. Promotes the closure of KCNA1, KCNA2 and KCNA5 channels 7,8,9,10,11,12,13,14,15,16. Accelerates KCNA4 channel closure 17,18,19,20. Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 21. Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 22,23. Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity 24. Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ion channel, Oxidoreductase, Voltage-gated channel
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Potassium transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NADP, Potassium
Gene summary (Entrez)i
Useful information about the gene from Entrez
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0004033[aldo-keto reductase (NADP) activity] GO:0005244[voltage-gated ion channel activity] GO:0005249[voltage-gated potassium channel activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016491[oxidoreductase activity] GO:0019904[protein domain specific binding] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0034220[ion transmembrane transport] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044224[juxtaparanode region of axon] GO:0044325[transmembrane transporter binding] GO:0055085[transmembrane transport] GO:0070402[NADPH binding] GO:0071805[potassium ion transmembrane transport] GO:0140678[molecular function inhibitor activity] GO:1901379[regulation of potassium ion transmembrane transport] GO:1902259[regulation of delayed rectifier potassium channel activity] GO:1902260[negative regulation of delayed rectifier potassium channel activity] GO:1903817[negative regulation of voltage-gated potassium channel activity]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0004033[aldo-keto reductase (NADP) activity] GO:0005244[voltage-gated ion channel activity] GO:0005249[voltage-gated potassium channel activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016491[oxidoreductase activity] GO:0019904[protein domain specific binding] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0034220[ion transmembrane transport] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044224[juxtaparanode region of axon] GO:0044325[transmembrane transporter binding] GO:0055085[transmembrane transport] GO:0070402[NADPH binding] GO:0071805[potassium ion transmembrane transport] GO:0140678[molecular function inhibitor activity] GO:1901379[regulation of potassium ion transmembrane transport] GO:1902259[regulation of delayed rectifier potassium channel activity] GO:1902260[negative regulation of delayed rectifier potassium channel activity] GO:1903817[negative regulation of voltage-gated potassium channel activity]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0004033[aldo-keto reductase (NADP) activity] GO:0005244[voltage-gated ion channel activity] GO:0005249[voltage-gated potassium channel activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016491[oxidoreductase activity] GO:0019904[protein domain specific binding] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0034220[ion transmembrane transport] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044224[juxtaparanode region of axon] GO:0044325[transmembrane transporter binding] GO:0055085[transmembrane transport] GO:0070402[NADPH binding] GO:0071805[potassium ion transmembrane transport] GO:0140678[molecular function inhibitor activity] GO:1901379[regulation of potassium ion transmembrane transport] GO:1902259[regulation of delayed rectifier potassium channel activity] GO:1902260[negative regulation of delayed rectifier potassium channel activity] GO:1903817[negative regulation of voltage-gated potassium channel activity]
The Human Protein Atlas project is funded
