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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q24.3
Chromosome location (bp)
75278826 - 75282230
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q6FG41 [Target identity:100%; Query identity:100%] Protein c-Fos
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001661[conditioned taste aversion] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0007399[nervous system development] GO:0007565[female pregnancy] GO:0007568[aging] GO:0009409[response to cold] GO:0009410[response to xenobiotic stimulus] GO:0009416[response to light stimulus] GO:0009612[response to mechanical stimulus] GO:0009629[response to gravity] GO:0009636[response to toxic substance] GO:0010468[regulation of gene expression] GO:0014070[response to organic cyclic compound] GO:0014823[response to activity] GO:0014856[skeletal muscle cell proliferation] GO:0016020[membrane] GO:0030316[osteoclast differentiation] GO:0030431[sleep] GO:0031668[cellular response to extracellular stimulus] GO:0032496[response to lipopolysaccharide] GO:0032570[response to progesterone] GO:0032868[response to insulin] GO:0032870[cellular response to hormone stimulus] GO:0032993[protein-DNA complex] GO:0034097[response to cytokine] GO:0034224[cellular response to zinc ion starvation] GO:0034614[cellular response to reactive oxygen species] GO:0035902[response to immobilization stress] GO:0035914[skeletal muscle cell differentiation] GO:0035976[transcription factor AP-1 complex] GO:0035994[response to muscle stretch] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043565[sequence-specific DNA binding] GO:0044877[protein-containing complex binding] GO:0045471[response to ethanol] GO:0045672[positive regulation of osteoclast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048545[response to steroid hormone] GO:0051412[response to corticosterone] GO:0051450[myoblast proliferation] GO:0051591[response to cAMP] GO:0060395[SMAD protein signal transduction] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070412[R-SMAD binding] GO:0071276[cellular response to cadmium ion] GO:0071277[cellular response to calcium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071456[cellular response to hypoxia] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140467[integrated stress response signaling] GO:1901216[positive regulation of neuron death] GO:1902895[positive regulation of miRNA transcription] GO:1903131[mononuclear cell differentiation] GO:1904628[cellular response to phorbol 13-acetate 12-myristate] GO:1990646[cellular response to prolactin] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0032993[protein-DNA complex] GO:0034614[cellular response to reactive oxygen species] GO:0035976[transcription factor AP-1 complex] GO:0042802[identical protein binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060395[SMAD protein signal transduction] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070412[R-SMAD binding] GO:0071276[cellular response to cadmium ion] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140467[integrated stress response signaling] GO:1901216[positive regulation of neuron death] GO:1902895[positive regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0032993[protein-DNA complex] GO:0034614[cellular response to reactive oxygen species] GO:0035976[transcription factor AP-1 complex] GO:0042802[identical protein binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0060395[SMAD protein signal transduction] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070412[R-SMAD binding] GO:0071276[cellular response to cadmium ion] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140467[integrated stress response signaling] GO:1901216[positive regulation of neuron death] GO:1902895[positive regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
