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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p25.3
Chromosome location (bp)
9779967 - 9793011
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000124[SAGA complex] GO:0000278[mitotic cell cycle] GO:0001932[regulation of protein phosphorylation] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006282[regulation of DNA repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0010628[positive regulation of gene expression] GO:0016573[histone acetylation] GO:0016922[nuclear receptor binding] GO:0019904[protein domain specific binding] GO:0030374[nuclear receptor coactivator activity] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0031063[regulation of histone deacetylation] GO:0031647[regulation of protein stability] GO:0033276[transcription factor TFTC complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0043229[intracellular organelle] GO:0043484[regulation of RNA splicing] GO:0043966[histone H3 acetylation] GO:0044154[histone H3-K14 acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045995[regulation of embryonic development] GO:0051302[regulation of cell division] GO:0051726[regulation of cell cycle] GO:0072686[mitotic spindle] GO:0090043[regulation of tubulin deacetylation] GO:0140672[ATAC complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000124[SAGA complex] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006282[regulation of DNA repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0010628[positive regulation of gene expression] GO:0016573[histone acetylation] GO:0016922[nuclear receptor binding] GO:0019904[protein domain specific binding] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0031063[regulation of histone deacetylation] GO:0033276[transcription factor TFTC complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0043229[intracellular organelle] GO:0043484[regulation of RNA splicing] GO:0043966[histone H3 acetylation] GO:0044154[histone H3-K14 acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045995[regulation of embryonic development] GO:0051302[regulation of cell division] GO:0051726[regulation of cell cycle] GO:0072686[mitotic spindle] GO:0090043[regulation of tubulin deacetylation] GO:0140672[ATAC complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000124[SAGA complex] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006282[regulation of DNA repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0010628[positive regulation of gene expression] GO:0016573[histone acetylation] GO:0016922[nuclear receptor binding] GO:0019904[protein domain specific binding] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0031063[regulation of histone deacetylation] GO:0033276[transcription factor TFTC complex] GO:0035521[monoubiquitinated histone deubiquitination] GO:0035522[monoubiquitinated histone H2A deubiquitination] GO:0043229[intracellular organelle] GO:0043484[regulation of RNA splicing] GO:0043966[histone H3 acetylation] GO:0044154[histone H3-K14 acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045995[regulation of embryonic development] GO:0051302[regulation of cell division] GO:0051726[regulation of cell cycle] GO:0072686[mitotic spindle] GO:0090043[regulation of tubulin deacetylation] GO:0140672[ATAC complex]
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