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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q31.3
Chromosome location (bp)
154583126 - 154590742
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Cardiovascular diseases Hematologic diseases Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0005102[signaling receptor binding] GO:0005198[structural molecule activity] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005886[plasma membrane] GO:0007160[cell-matrix adhesion] GO:0007596[blood coagulation] GO:0007599[hemostasis] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0030168[platelet activation] GO:0031091[platelet alpha granule] GO:0031093[platelet alpha granule lumen] GO:0031639[plasminogen activation] GO:0034116[positive regulation of heterotypic cell-cell adhesion] GO:0042730[fibrinolysis] GO:0043152[induction of bacterial agglutination] GO:0045087[innate immune response] GO:0045907[positive regulation of vasoconstriction] GO:0045921[positive regulation of exocytosis] GO:0046872[metal ion binding] GO:0050714[positive regulation of protein secretion] GO:0050839[cell adhesion molecule binding] GO:0051258[protein polymerization] GO:0051592[response to calcium ion] GO:0062023[collagen-containing extracellular matrix] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0072377[blood coagulation, common pathway] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0090277[positive regulation of peptide hormone secretion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903561[extracellular vesicle] GO:2000352[negative regulation of endothelial cell apoptotic process]
Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Cardiovascular diseases Hematologic diseases Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0005102[signaling receptor binding] GO:0005198[structural molecule activity] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005886[plasma membrane] GO:0007160[cell-matrix adhesion] GO:0007596[blood coagulation] GO:0007599[hemostasis] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0030168[platelet activation] GO:0031091[platelet alpha granule] GO:0031093[platelet alpha granule lumen] GO:0031639[plasminogen activation] GO:0034116[positive regulation of heterotypic cell-cell adhesion] GO:0042730[fibrinolysis] GO:0043152[induction of bacterial agglutination] GO:0045087[innate immune response] GO:0045907[positive regulation of vasoconstriction] GO:0045921[positive regulation of exocytosis] GO:0046872[metal ion binding] GO:0050714[positive regulation of protein secretion] GO:0050839[cell adhesion molecule binding] GO:0051258[protein polymerization] GO:0051592[response to calcium ion] GO:0062023[collagen-containing extracellular matrix] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0072377[blood coagulation, common pathway] GO:0072378[blood coagulation, fibrin clot formation] GO:0072562[blood microparticle] GO:0090277[positive regulation of peptide hormone secretion] GO:0110165[cellular anatomical entity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903561[extracellular vesicle] GO:2000352[negative regulation of endothelial cell apoptotic process]
The Human Protein Atlas project is funded
