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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q23.31
Chromosome location (bp)
87862563 - 87971930
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins 1,2. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 3,4,5. Tumor suppressor, the lipid phosphatase activity is critical for its tumor suppressor function 6,7,8. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival 9. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation 10. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement 11. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation 12. Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation 13. Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation 14. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability 15,16....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Lipid metabolism, Neurogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lipid-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P60484 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
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F6KD01 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
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Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001933[negative regulation of protein phosphorylation] GO:0004438[phosphatidylinositol-3-phosphatase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0006915[apoptotic process] GO:0007270[neuron-neuron synaptic transmission] GO:0007399[nervous system development] GO:0007416[synapse assembly] GO:0007417[central nervous system development] GO:0007507[heart development] GO:0007611[learning or memory] GO:0007626[locomotory behavior] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010975[regulation of neuron projection development] GO:0010977[negative regulation of neuron projection development] GO:0010997[anaphase-promoting complex binding] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014067[negative regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016311[dephosphorylation] GO:0016314[phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016324[apical plasma membrane] GO:0016477[cell migration] GO:0016605[PML body] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017018[myosin phosphatase activity] GO:0019899[enzyme binding] GO:0021542[dentate gyrus development] GO:0021955[central nervous system neuron axonogenesis] GO:0030165[PDZ domain binding] GO:0030336[negative regulation of cell migration] GO:0031647[regulation of protein stability] GO:0032286[central nervous system myelin maintenance] GO:0032535[regulation of cellular component size] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0033555[multicellular organismal response to stress] GO:0035176[social behavior] GO:0035749[myelin sheath adaxonal region] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043197[dendritic spine] GO:0043220[Schmidt-Lanterman incisure] GO:0043491[protein kinase B signaling] GO:0045202[synapse] GO:0045475[locomotor rhythm] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045792[negative regulation of cell size] GO:0046621[negative regulation of organ growth] GO:0046855[inositol phosphate dephosphorylation] GO:0046856[phosphatidylinositol dephosphorylation] GO:0048853[forebrain morphogenesis] GO:0048854[brain morphogenesis] GO:0048870[cell motility] GO:0050771[negative regulation of axonogenesis] GO:0050821[protein stabilization] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051548[negative regulation of keratinocyte migration] GO:0051717[inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity] GO:0051800[phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity] GO:0051895[negative regulation of focal adhesion assembly] GO:0051896[regulation of protein kinase B signaling] GO:0051898[negative regulation of protein kinase B signaling] GO:0052866[phosphatidylinositol phosphate phosphatase activity] GO:0060024[rhythmic synaptic transmission] GO:0060070[canonical Wnt signaling pathway] GO:0060074[synapse maturation] GO:0060134[prepulse inhibition] GO:0060997[dendritic spine morphogenesis] GO:0061002[negative regulation of dendritic spine morphogenesis] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071257[cellular response to electrical stimulus] GO:0090394[negative regulation of excitatory postsynaptic potential] GO:0097105[presynaptic membrane assembly] GO:0097107[postsynaptic density assembly] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1903690[negative regulation of wound healing, spreading of epidermal cells] GO:1903984[positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1990381[ubiquitin-specific protease binding] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle] GO:2000463[positive regulation of excitatory postsynaptic potential] GO:2000773[negative regulation of cellular senescence] GO:2000808[negative regulation of synaptic vesicle clustering]
A0A087X033 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
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Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
P60484 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Show all
F6KD01 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Show all
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933[negative regulation of protein phosphorylation] GO:0004438[phosphatidylinositol-3-phosphatase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0006915[apoptotic process] GO:0007270[neuron-neuron synaptic transmission] GO:0007399[nervous system development] GO:0007416[synapse assembly] GO:0007417[central nervous system development] GO:0007507[heart development] GO:0007611[learning or memory] GO:0007626[locomotory behavior] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010975[regulation of neuron projection development] GO:0010977[negative regulation of neuron projection development] GO:0010997[anaphase-promoting complex binding] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014067[negative regulation of phosphatidylinositol 3-kinase signaling] GO:0014069[postsynaptic density] GO:0016311[dephosphorylation] GO:0016314[phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016324[apical plasma membrane] GO:0016477[cell migration] GO:0016605[PML body] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017018[myosin phosphatase activity] GO:0019899[enzyme binding] GO:0021542[dentate gyrus development] GO:0021955[central nervous system neuron axonogenesis] GO:0030165[PDZ domain binding] GO:0030336[negative regulation of cell migration] GO:0031647[regulation of protein stability] GO:0032286[central nervous system myelin maintenance] GO:0032535[regulation of cellular component size] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0033555[multicellular organismal response to stress] GO:0035176[social behavior] GO:0035749[myelin sheath adaxonal region] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043197[dendritic spine] GO:0043220[Schmidt-Lanterman incisure] GO:0043491[protein kinase B signaling] GO:0045202[synapse] GO:0045475[locomotor rhythm] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045792[negative regulation of cell size] GO:0046621[negative regulation of organ growth] GO:0046855[inositol phosphate dephosphorylation] GO:0046856[phosphatidylinositol dephosphorylation] GO:0048853[forebrain morphogenesis] GO:0048854[brain morphogenesis] GO:0048870[cell motility] GO:0050771[negative regulation of axonogenesis] GO:0050821[protein stabilization] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051548[negative regulation of keratinocyte migration] GO:0051717[inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity] GO:0051800[phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity] GO:0051895[negative regulation of focal adhesion assembly] GO:0051896[regulation of protein kinase B signaling] GO:0051898[negative regulation of protein kinase B signaling] GO:0052866[phosphatidylinositol phosphate phosphatase activity] GO:0060024[rhythmic synaptic transmission] GO:0060070[canonical Wnt signaling pathway] GO:0060074[synapse maturation] GO:0060134[prepulse inhibition] GO:0060997[dendritic spine morphogenesis] GO:0061002[negative regulation of dendritic spine morphogenesis] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071257[cellular response to electrical stimulus] GO:0090394[negative regulation of excitatory postsynaptic potential] GO:0097105[presynaptic membrane assembly] GO:0097107[postsynaptic density assembly] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1903690[negative regulation of wound healing, spreading of epidermal cells] GO:1903984[positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1990381[ubiquitin-specific protease binding] GO:2000060[positive regulation of ubiquitin-dependent protein catabolic process] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle] GO:2000463[positive regulation of excitatory postsynaptic potential] GO:2000773[negative regulation of cellular senescence] GO:2000808[negative regulation of synaptic vesicle clustering]
A0A8I5KSF9 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Metabolic proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
F6KD01 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
