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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p12
Chromosome location (bp)
79157003 - 79159753
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
[Regenerating islet-derived protein 3-alpha 15 kDa form]: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan 1. Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antimicrobial
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Acute phase, Inflammatory response
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lectin
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q06141 [Direct mapping] Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form
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Q53S56 [Target identity:100%; Query identity:100%] Proliferation-inducing protein 34; Proliferation-inducing protein 42; Regenerating islet-derived 3 alpha, isoform CRA_a; Uncharacterized protein PAP; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA
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Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0007157[heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008284[positive regulation of cell population proliferation] GO:0010838[positive regulation of keratinocyte proliferation] GO:0030246[carbohydrate binding] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0042834[peptidoglycan binding] GO:0043434[response to peptide hormone] GO:0044278[cell wall disruption in another organism] GO:0045617[negative regulation of keratinocyte differentiation] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0070492[oligosaccharide binding] GO:0090303[positive regulation of wound healing]
Q06141 [Direct mapping] Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form
Show all
Q53S56 [Target identity:100%; Query identity:100%] Proliferation-inducing protein 34; Proliferation-inducing protein 42; Regenerating islet-derived 3 alpha, isoform CRA_a; Uncharacterized protein PAP; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA
Show all
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0007157[heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008284[positive regulation of cell population proliferation] GO:0010838[positive regulation of keratinocyte proliferation] GO:0030246[carbohydrate binding] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0042834[peptidoglycan binding] GO:0043434[response to peptide hormone] GO:0044278[cell wall disruption in another organism] GO:0045617[negative regulation of keratinocyte differentiation] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0070492[oligosaccharide binding] GO:0090303[positive regulation of wound healing]
Q06141 [Direct mapping] Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form
Show all
Q53S56 [Target identity:100%; Query identity:100%] Proliferation-inducing protein 34; Proliferation-inducing protein 42; Regenerating islet-derived 3 alpha, isoform CRA_a; Uncharacterized protein PAP; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA
Show all
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0007157[heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008284[positive regulation of cell population proliferation] GO:0010838[positive regulation of keratinocyte proliferation] GO:0030246[carbohydrate binding] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0042834[peptidoglycan binding] GO:0043434[response to peptide hormone] GO:0044278[cell wall disruption in another organism] GO:0045617[negative regulation of keratinocyte differentiation] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0070492[oligosaccharide binding] GO:0090303[positive regulation of wound healing]
The Human Protein Atlas project is funded
