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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p13.3
Chromosome location (bp)
34689570 - 34691276
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Chemotaxis, Inflammatory response
Gene summary (Entrez)i
Useful information about the gene from Entrez
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001768[establishment of T cell polarity] GO:0001771[immunological synapse formation] GO:0002407[dendritic cell chemotaxis] GO:0002408[myeloid dendritic cell chemotaxis] GO:0002548[monocyte chemotaxis] GO:0002606[positive regulation of dendritic cell antigen processing and presentation] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006874[cellular calcium ion homeostasis] GO:0006935[chemotaxis] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007154[cell communication] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0008009[chemokine activity] GO:0009615[response to virus] GO:0010560[positive regulation of glycoprotein biosynthetic process] GO:0016477[cell migration] GO:0030593[neutrophil chemotaxis] GO:0031295[T cell costimulation] GO:0031732[CCR7 chemokine receptor binding] GO:0031735[CCR10 chemokine receptor binding] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032735[positive regulation of interleukin-12 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0034695[response to prostaglandin E] GO:0042102[positive regulation of T cell proliferation] GO:0042379[chemokine receptor binding] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043507[positive regulation of JUN kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045627[positive regulation of T-helper 1 cell differentiation] GO:0045807[positive regulation of endocytosis] GO:0045860[positive regulation of protein kinase activity] GO:0046330[positive regulation of JNK cascade] GO:0048020[CCR chemokine receptor binding] GO:0048247[lymphocyte chemotaxis] GO:0048260[positive regulation of receptor-mediated endocytosis] GO:0048469[cell maturation] GO:0050921[positive regulation of chemotaxis] GO:0051209[release of sequestered calcium ion into cytosol] GO:0051897[positive regulation of protein kinase B signaling] GO:0060326[cell chemotaxis] GO:0060491[regulation of cell projection assembly] GO:0070098[chemokine-mediated signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071346[cellular response to interferon-gamma] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071731[response to nitric oxide] GO:0090023[positive regulation of neutrophil chemotaxis] GO:0097029[mature conventional dendritic cell differentiation] GO:0098586[cellular response to virus] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:2000147[positive regulation of cell motility] GO:2000549[positive regulation of dendritic cell dendrite assembly] GO:2000669[negative regulation of dendritic cell apoptotic process]
The Human Protein Atlas project is funded
