GENERAL INFORMATIONi
Gene namei MYD88
Synonyms
Gene descriptioni MYD88 innate immune signal transduction adaptor
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 3
Cytoband p22.2
Chromosome location (bp) 38138478 - 38143024
Number of transcriptsi 8
Ensembl ENSG00000172936 (version 109)
Entrez gene 4615
HGNC HGNC:7562
UniProt Q99836 (UniProt - Evidence at protein level)
neXtProt NX_Q99836
GeneCards MYD88
Antibodypedia MYD88 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response 1, 2, 3. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response 4, 5, 6. Increases IL-8 transcription 7. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation 8. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). show less
Biological process (UniProt)i Antiviral defense, Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)i This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
MYD88-201
ENSP00000379625
ENST00000396334
Q99836
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008063 [Toll signaling pathway]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0034158 [toll-like receptor 8 signaling pathway]
GO:0035325 [Toll-like receptor binding]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042832 [defense response to protozoan]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
Show all
 296 aa
33.2 kDa 		No 0
MYD88-203
ENSP00000401399
ENST00000417037
Q99836
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
A0A0A0MSI9
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008063 [Toll signaling pathway]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0034158 [toll-like receptor 8 signaling pathway]
GO:0035325 [Toll-like receptor binding]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042832 [defense response to protozoan]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
Show all
 251 aa
28.3 kDa 		No 0
MYD88-204
ENSP00000391753
ENST00000421516
Q99836
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008063 [Toll signaling pathway]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0034158 [toll-like receptor 8 signaling pathway]
GO:0035325 [Toll-like receptor binding]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042832 [defense response to protozoan]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
Show all
 304 aa
34.1 kDa 		No 0
MYD88-209
ENSP00000497991
ENST00000650112
Q99836
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
A0A3B3ITY3
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008063 [Toll signaling pathway]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0034158 [toll-like receptor 8 signaling pathway]
GO:0035325 [Toll-like receptor binding]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042832 [defense response to protozoan]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
Show all
 146 aa
15.8 kDa 		No 0
MYD88-210
ENSP00000498360
ENST00000650905
Q99836
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002238 [response to molecule of fungal origin]
GO:0002269 [leukocyte activation involved in inflammatory response]
GO:0002283 [neutrophil activation involved in immune response]
GO:0002376 [immune system process]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005102 [signaling receptor binding]
GO:0005121 [Toll binding]
GO:0005123 [death receptor binding]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0008063 [Toll signaling pathway]
GO:0009615 [response to virus]
GO:0009682 [induced systemic resistance]
GO:0010008 [endosome membrane]
GO:0010243 [response to organonitrogen compound]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0014069 [postsynaptic density]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0016064 [immunoglobulin mediated immune response]
GO:0016571 [histone methylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032481 [positive regulation of type I interferon production]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0032675 [regulation of interleukin-6 production]
GO:0032680 [regulation of tumor necrosis factor production]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032991 [protein-containing complex]
GO:0034158 [toll-like receptor 8 signaling pathway]
GO:0035325 [Toll-like receptor binding]
GO:0042127 [regulation of cell population proliferation]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042832 [defense response to protozoan]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043200 [response to amino acid]
GO:0043588 [skin development]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070944 [neutrophil-mediated killing of bacterium]
GO:0070976 [TIR domain binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:0140674 [ATP-dependent histone chaperone activity]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
GO:1902622 [regulation of neutrophil migration]
GO:2000338 [regulation of chemokine (C-X-C motif) ligand 1 production]
GO:2000341 [regulation of chemokine (C-X-C motif) ligand 2 production]
Show all
 296 aa
33.2 kDa 		No 0
MYD88-211
ENSP00000499012
ENST00000651800
Q99836
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
A0A3F2YP85
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008063 [Toll signaling pathway]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0034158 [toll-like receptor 8 signaling pathway]
GO:0035325 [Toll-like receptor binding]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042832 [defense response to protozoan]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071260 [cellular response to mechanical stimulus]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1900227 [positive regulation of NLRP3 inflammasome complex assembly]
Show all
 191 aa
20.8 kDa 		No 0
MYD88-212
ENSP00000498576
ENST00000652213
A0A494C0J8
[Direct mapping] Myeloid differentiation primary response protein MyD88
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070976 [TIR domain binding]
Show all
 245 aa
27.1 kDa 		No 0
MYD88-216
ENSP00000514121
ENST00000699086
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
   Immune system diseases
   Primary immunodeficiency
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070976 [TIR domain binding]
Show all
 179 aa
20.3 kDa 		No 1

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