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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes FDA approved drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.1
Chromosome location (bp)
64234584 - 64239264
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Growth factor, Heparin-binding, Mitogen
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0001666[response to hypoxia] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002040[sprouting angiogenesis] GO:0005172[vascular endothelial growth factor receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006493[protein O-linked glycosylation] GO:0007165[signal transduction] GO:0007507[heart development] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0031093[platelet alpha granule lumen] GO:0035470[positive regulation of vascular wound healing] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0043183[vascular endothelial growth factor receptor 1 binding] GO:0045766[positive regulation of angiogenesis] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048018[receptor ligand activity] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0050930[induction of positive chemotaxis] GO:0051781[positive regulation of cell division] GO:0060048[cardiac muscle contraction] GO:0060754[positive regulation of mast cell chemotaxis] GO:0060976[coronary vasculature development]
P49765 [Direct mapping] Vascular endothelial growth factor B
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0001666[response to hypoxia] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002040[sprouting angiogenesis] GO:0005172[vascular endothelial growth factor receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031093[platelet alpha granule lumen] GO:0035470[positive regulation of vascular wound healing] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0042056[chemoattractant activity] GO:0043066[negative regulation of apoptotic process] GO:0043183[vascular endothelial growth factor receptor 1 binding] GO:0043524[negative regulation of neuron apoptotic process] GO:0045766[positive regulation of angiogenesis] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048018[receptor ligand activity] GO:0050918[positive chemotaxis] GO:0050930[induction of positive chemotaxis] GO:0051781[positive regulation of cell division] GO:0051897[positive regulation of protein kinase B signaling] GO:0060754[positive regulation of mast cell chemotaxis] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
The Human Protein Atlas project is funded
