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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Signal transducer and activator of transcription 5B
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.2
Chromosome location (bp)
42199176 - 42288633
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Carries out a dual function: signal transduction and activation of transcription 1. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P51692 [Direct mapping] Signal transducer and activator of transcription 5B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000278[mitotic cell cycle] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001553[luteinization] GO:0001779[natural killer cell differentiation] GO:0001787[natural killer cell proliferation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006952[defense response] GO:0007165[signal transduction] GO:0007259[receptor signaling pathway via JAK-STAT] GO:0007548[sex differentiation] GO:0007565[female pregnancy] GO:0007595[lactation] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0019218[regulation of steroid metabolic process] GO:0019221[cytokine-mediated signaling pathway] GO:0019530[taurine metabolic process] GO:0019915[lipid storage] GO:0030098[lymphocyte differentiation] GO:0030155[regulation of cell adhesion] GO:0030183[B cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030856[regulation of epithelial cell differentiation] GO:0032355[response to estradiol] GO:0032743[positive regulation of interleukin-2 production] GO:0032819[positive regulation of natural killer cell proliferation] GO:0032825[positive regulation of natural killer cell differentiation] GO:0032870[cellular response to hormone stimulus] GO:0033028[myeloid cell apoptotic process] GO:0033033[negative regulation of myeloid cell apoptotic process] GO:0033077[T cell differentiation in thymus] GO:0035259[nuclear glucocorticoid receptor binding] GO:0040014[regulation of multicellular organism growth] GO:0040018[] GO:0042104[positive regulation of activated T cell proliferation] GO:0042127[regulation of cell population proliferation] GO:0042267[natural killer cell mediated cytotoxicity] GO:0042448[progesterone metabolic process] GO:0042492[gamma-delta T cell differentiation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043029[T cell homeostasis] GO:0043434[response to peptide hormone] GO:0045579[positive regulation of B cell differentiation] GO:0045588[positive regulation of gamma-delta T cell differentiation] GO:0045621[positive regulation of lymphocyte differentiation] GO:0045647[negative regulation of erythrocyte differentiation] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045931[positive regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046543[development of secondary female sexual characteristics] GO:0046544[development of secondary male sexual characteristics] GO:0046983[protein dimerization activity] GO:0048541[Peyer's patch development] GO:0050729[positive regulation of inflammatory response] GO:0050798[activated T cell proliferation] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT] GO:0070669[response to interleukin-2] GO:0070670[response to interleukin-4] GO:0070672[response to interleukin-15] GO:0071363[cellular response to growth factor stimulus] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097531[mast cell migration]
C9J4I3 [Direct mapping] Signal transducer and activator of transcription 5B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
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GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0060397[growth hormone receptor signaling pathway via JAK-STAT]
The Human Protein Atlas project is funded
