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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q25.2
Chromosome location (bp)
154272546 - 154324487
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures 1,2,3,4. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses 5,6,7,8,9. G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) 10,11,12,13,14,15. Plays a role in genomic integrity 16. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription 17,18,19,20,21,22. Plays a role in transcriptional regulation 23,24. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression 25. Plays a role in post-transcriptional regulation 26. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage 27. Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability 28,29. Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression 30. Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively 31. Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation 32,33. Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay 34. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0000781[chromosome, telomeric region] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001503[ossification] GO:0002151[G-quadruplex RNA binding] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003678[DNA helicase activity] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003724[RNA helicase activity] GO:0003725[double-stranded RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006359[regulation of transcription by RNA polymerase III] GO:0006417[regulation of translation] GO:0007283[spermatogenesis] GO:0008094[ATP-dependent activity, acting on DNA] GO:0010494[cytoplasmic stress granule] GO:0010501[RNA secondary structure unwinding] GO:0010628[positive regulation of gene expression] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0017148[negative regulation of translation] GO:0030154[cell differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031442[positive regulation of mRNA 3'-end processing] GO:0032206[positive regulation of telomere maintenance] GO:0032508[DNA duplex unwinding] GO:0032727[positive regulation of interferon-alpha production] GO:0034605[cellular response to heat] GO:0034644[cellular response to UV] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0042826[histone deacetylase binding] GO:0042995[cell projection] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043204[perikaryon] GO:0043488[regulation of mRNA stability] GO:0044806[G-quadruplex DNA unwinding] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0046872[metal ion binding] GO:0048027[mRNA 5'-UTR binding] GO:0051607[defense response to virus] GO:0051880[G-quadruplex DNA binding] GO:0051891[positive regulation of cardioblast differentiation] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061003[positive regulation of dendritic spine morphogenesis] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0070034[telomerase RNA binding] GO:0070062[extracellular exosome] GO:0070883[pre-miRNA binding] GO:0090669[telomerase RNA stabilization] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1901534[positive regulation of hematopoietic progenitor cell differentiation] GO:1903843[cellular response to arsenite ion] GO:1904358[positive regulation of telomere maintenance via telomere lengthening] GO:1904582[positive regulation of intracellular mRNA localization] GO:2000767[positive regulation of cytoplasmic translation]
Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0000781[chromosome, telomeric region] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001503[ossification] GO:0002151[G-quadruplex RNA binding] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003678[DNA helicase activity] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003724[RNA helicase activity] GO:0003725[double-stranded RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006359[regulation of transcription by RNA polymerase III] GO:0006417[regulation of translation] GO:0007283[spermatogenesis] GO:0008094[ATP-dependent activity, acting on DNA] GO:0010494[cytoplasmic stress granule] GO:0010501[RNA secondary structure unwinding] GO:0010628[positive regulation of gene expression] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0017148[negative regulation of translation] GO:0030154[cell differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031442[positive regulation of mRNA 3'-end processing] GO:0032206[positive regulation of telomere maintenance] GO:0032508[DNA duplex unwinding] GO:0032727[positive regulation of interferon-alpha production] GO:0034605[cellular response to heat] GO:0034644[cellular response to UV] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0042826[histone deacetylase binding] GO:0042995[cell projection] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043204[perikaryon] GO:0043488[regulation of mRNA stability] GO:0044806[G-quadruplex DNA unwinding] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0046872[metal ion binding] GO:0048027[mRNA 5'-UTR binding] GO:0051607[defense response to virus] GO:0051880[G-quadruplex DNA binding] GO:0051891[positive regulation of cardioblast differentiation] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061003[positive regulation of dendritic spine morphogenesis] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0070034[telomerase RNA binding] GO:0070062[extracellular exosome] GO:0070883[pre-miRNA binding] GO:0090669[telomerase RNA stabilization] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1901534[positive regulation of hematopoietic progenitor cell differentiation] GO:1903843[cellular response to arsenite ion] GO:1904358[positive regulation of telomere maintenance via telomere lengthening] GO:1904582[positive regulation of intracellular mRNA localization] GO:2000767[positive regulation of cytoplasmic translation]
Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0000781[chromosome, telomeric region] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001503[ossification] GO:0002151[G-quadruplex RNA binding] GO:0002376[immune system process] GO:0002735[positive regulation of myeloid dendritic cell cytokine production] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003678[DNA helicase activity] GO:0003697[single-stranded DNA binding] GO:0003723[RNA binding] GO:0003724[RNA helicase activity] GO:0003725[double-stranded RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006359[regulation of transcription by RNA polymerase III] GO:0006417[regulation of translation] GO:0007283[spermatogenesis] GO:0008094[ATP-dependent activity, acting on DNA] GO:0009615[response to virus] GO:0010494[cytoplasmic stress granule] GO:0010501[RNA secondary structure unwinding] GO:0010628[positive regulation of gene expression] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0017148[negative regulation of translation] GO:0030154[cell differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031442[positive regulation of mRNA 3'-end processing] GO:0032206[positive regulation of telomere maintenance] GO:0032508[DNA duplex unwinding] GO:0032727[positive regulation of interferon-alpha production] GO:0034605[cellular response to heat] GO:0034644[cellular response to UV] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0042826[histone deacetylase binding] GO:0042995[cell projection] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043204[perikaryon] GO:0043330[response to exogenous dsRNA] GO:0043488[regulation of mRNA stability] GO:0044806[G-quadruplex DNA unwinding] GO:0045087[innate immune response] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0045995[regulation of embryonic development] GO:0046872[metal ion binding] GO:0048027[mRNA 5'-UTR binding] GO:0051607[defense response to virus] GO:0051880[G-quadruplex DNA binding] GO:0051891[positive regulation of cardioblast differentiation] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061003[positive regulation of dendritic spine morphogenesis] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0070034[telomerase RNA binding] GO:0070062[extracellular exosome] GO:0070883[pre-miRNA binding] GO:0090669[telomerase RNA stabilization] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1901534[positive regulation of hematopoietic progenitor cell differentiation] GO:1903843[cellular response to arsenite ion] GO:1904358[positive regulation of telomere maintenance via telomere lengthening] GO:1904582[positive regulation of intracellular mRNA localization] GO:2000767[positive regulation of cytoplasmic translation]
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