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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q24.1
Chromosome location (bp)
86566829 - 86569728
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional activator. Might be involved in the formation of special mesenchymal tissues....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Developmental protein, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of skin Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001216[DNA-binding transcription activator activity] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001501[skeletal system development] GO:0001503[ossification] GO:0001568[blood vessel development] GO:0001569[branching involved in blood vessel morphogenesis] GO:0001656[metanephros development] GO:0001657[ureteric bud development] GO:0001756[somitogenesis] GO:0001822[kidney development] GO:0001945[lymph vessel development] GO:0001946[lymphangiogenesis] GO:0001974[blood vessel remodeling] GO:0003007[heart morphogenesis] GO:0003275[apoptotic process involved in outflow tract morphogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007219[Notch signaling pathway] GO:0007498[mesoderm development] GO:0007507[heart development] GO:0008283[cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009725[response to hormone] GO:0010595[positive regulation of endothelial cell migration] GO:0014032[neural crest cell development] GO:0016604[nuclear body] GO:0030154[cell differentiation] GO:0030199[collagen fibril organization] GO:0031490[chromatin DNA binding] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0035050[embryonic heart tube development] GO:0035470[positive regulation of vascular wound healing] GO:0042802[identical protein binding] GO:0043010[camera-type eye development] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046620[regulation of organ growth] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048341[paraxial mesoderm formation] GO:0048343[paraxial mesodermal cell fate commitment] GO:0048701[embryonic cranial skeleton morphogenesis] GO:0048703[embryonic viscerocranium morphogenesis] GO:0048704[embryonic skeletal system morphogenesis] GO:0048844[artery morphogenesis] GO:0055010[ventricular cardiac muscle tissue morphogenesis] GO:0060038[cardiac muscle cell proliferation] GO:0072011[glomerular endothelium development] GO:0072112[podocyte differentiation] GO:0072144[glomerular mesangial cell development] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0097746[blood vessel diameter maintenance] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1902257[negative regulation of apoptotic process involved in outflow tract morphogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990841[promoter-specific chromatin binding]
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